Results 41 to 50 of about 75,068 (344)
Poria cocos Extract from Mushrooms Stimulates Aquaporin-3 via the PI3K/Akt/mTOR Signaling Pathway
Clinical, Cosmetic and Investigational Dermatology, 2022 Sung-Gu Park,1,* Il-Joo Jo,2,* Seol-A Park,3 Min-Cheol Park,1 Yeun-Ja Mun4 1Department of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Wonkwang University, Iksan, South Korea; 2Central Stroke Center ...
Park SG, Jo IJ, Park SA, Park MC, Mun YJ
doaj
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
Journal of Biomedical Sciences, 2020 The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy.
Terunao Takahara +4 more
semanticscholar +1 more source
A Wacky Bridge to mTORC1 Dimerization [PDF]
Developmental Cell, 2016 The activity of the mTORC1 protein complex depends on multiple metabolic inputs that regulate dimerization, recruitment to the lysosome, and activation. In this issue of Developmental Cell, David-Morrison et al. (2016) show that the Drosophila protein Wacky and its mammalian counterpart WAC act as adaptors in the process of mTORC1 dimerization.
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4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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Transcriptional regulation of mTORC1 in cancer
Oncotarget, 2018 no abstract ...
Di Malta, Chiara, Ballabio, Andrea
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mTORC1 as the main gateway to autophagy [PDF]
Essays in Biochemistry, 2017 Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when conditions are favourable. In order to maintain cellular homoeostasis, a tight regulation between the synthesis and degradation of cellular components is essential.
Elsje G. Otten +2 more
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PIKFYVE-dependent regulation of MTORC1 and TFEB
Autophagy Reports, 2022 TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin kinase) complex
Junya Hasegawa +2 more
doaj +1 more source
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea
EMBO Molecular Medicine, 2021 Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling is hyperactivated in the skin, especially in the epidermis, of both rosacea patients and a ...
Z. Deng +20 more
semanticscholar +1 more source
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma
Autophagy Reports, 2022 The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 ...
Sujoy Bhattacharya +2 more
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Regulation of mTORC1 Signaling by pH
PLoS ONE, 2011 Acidification of the cytoplasm and the extracellular environment is associated with many physiological and pathological conditions, such as intense exercise, hypoxia and tumourigenesis. Acidification affects important cellular functions including protein synthesis, growth, and proliferation.
Michel Roberge +8 more
openaire +5 more sources