Results 51 to 60 of about 75,068 (344)

mTORC1 maintains metabolic balance [PDF]

Cell Research, 2015
Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.
Heesun Cheong, Daniel J. Klionsky
openaire   +3 more sources

RETREG3/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation

Autophagy Reports, 2022
Starvation is the most potent physiological inducer of autophagy, the catabolic process which degrades unessential cytosolic components to sustain cellular homeostasis and survival.
Giorgia Di Lorenzo, Francescopaolo Iavarone, Marianna Maddaluno, Paolo Grumati, Carmine Settembre   +4 more
doaj   +1 more source

Autophagy Function and Regulation in Kidney Disease

Biomolecules, 2020
Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular components.
Gur P. Kaushal, Kiran Chandrashekar, Luis A. Juncos, Sudhir V. Shah   +3 more
doaj   +1 more source

Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma

Molecular & Cellular Oncology, 2021
The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj   +1 more source

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome

Nature, 2020
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates 1 – 3 .
G. Napolitano, Chiara Di Malta, A. Esposito, Mariana E. G. de Araujo, S. Pece, G. Bertalot, M. Matarese, V. Benedetti, Angela Zampelli, T. Stasyk, Diletta Siciliano, Alessandro Venuta, M. Cesana, C. Vilardo, E. Nusco, J. Monfregola, Alessia Calcagni’, P. P. Di Fiore, L. Huber, A. Ballabio   +19 more
semanticscholar   +1 more source

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation [PDF]

Science Signaling, 2014
A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions.
Deborah A. Sarkes, Ashley M. Mackey, John M. Asara, Lucia E. Rameh, Lucia E. Rameh, Ian Bettencourt   +5 more
openaire   +3 more sources

Regulation of mTORC1 by Upstream Stimuli [PDF]

Genes, 2020
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of ...
Chase H. Melick, Jenna L. Jewell
openaire   +3 more sources

Dietary Aronia melanocarpa extract enhances mTORC1 signaling, but has no effect on protein synthesis and protein breakdown-related signaling, in response to resistance exercise in rat skeletal muscle

Journal of the International Society of Sports Nutrition, 2019
Background Ursolic acid altered muscle protein metabolism in normal and resting conditions after acute resistance exercise, suggesting that eating fruits rich in ursolic acid could enhance muscle protein synthesis and decrease muscle degradation.
Yuhei Makanae, Satoru Ato, Kohei Kido, Satoshi Fujita   +3 more
doaj   +1 more source

Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy

Autophagy, 2021
Lipid accumulation often leads to lipotoxic injuries to hepatocytes, which can cause nonalcoholic steatohepatitis. The association of inflammation with lipid accumulation in liver tissue has been studied for decades; however, key mechanisms have been ...
Kunpeng Liu, Dongbo Qiu, Xue Liang, Yingqi Huang, Yao Wang, Xin Jia, Kun Li, Jingyuan Zhao, Cong Du, Xiusheng Qiu, J. Cui, Z. Xiao, Yunfei Qin, Qi Zhang   +13 more
semanticscholar   +1 more source

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

bioRxiv, 2020
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes.
Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Y. Wu, Matthew A Kukurugya, Claire F. Maher, Rushika M. Perera, M. Paulina Ordonez, R. Zoncu   +8 more
semanticscholar   +1 more source