Results 61 to 70 of about 75,068 (344)
Journal for ImmunoTherapy of Cancer, 2021 Background Metformin (Met) is the first-line treatment for type 2 diabetes mellitus and plays an effective role in treating various diseases, such as cardiovascular disease, neurodegenerative disease, cancer, and aging.
Mikako Nishida +11 more
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p16: cycling off the beaten path
Molecular & Cellular Oncology, 2019 p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-
Raquel Buj, Katherine M. Aird
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Skeletal muscle signaling response to concurrent endurance and resistance exercise
Journal of Physical Fitness and Sports Medicine, 2015 Concurrent training, which is a combination of resistance exercise (RE) and endurance exercise (EE) performed in succession, is used to improve both muscle strength and cardiovascular function.
Yuhei Makanae +2 more
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Clinical and Experimental Hypertension, 2023 Objective: Excessive proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is a core event of pulmonary hypertension (PH). Regulators of G protein signaling 10 (RGS10) can regulate cellular proliferation and cardiopulmonary ...
Sheng Hu +3 more
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The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Frontiers in Aging, 2021 The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes.
S. Fernandes, C. Demetriades
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Regulation of mTORC1 by PI3K signaling [PDF]
Trends in Cell Biology, 2015 The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation of mTORC1 [composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8(mLST8), 40-kDa proline-rich Akt substrate (PRAS40), and DEP domain ...
Lewis C. Cantley, Christian C. Dibble
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Regulation of mTORC1 by the Rag GTPases
Biochemical Society Transactions, 2023 The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neurodegeneration ...
Tshering D. Lama-Sherpa +2 more
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
eLife, 2021 The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function.
Maren Heimhalt +15 more
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Iranian Journal of Diabetes and Obesity, 2020 Objective: The aim of this study was to investigate the effect of 6 weeks of detraining after 12 weeks of high intensity interval training (HIIT) on the expression of AKT1 and mTORc1 genes in the left ventricle of wistar diabetic rats.
Farzaneh Soltanipour jounaghani +2 more
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AKAP13 couples GPCR signaling to mTORC1 inhibition.
PLoS Genetics, 2021 The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focused on
Shihai Zhang +10 more
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