TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners [PDF]
Autophagy, 2016 In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1.
Zheng, Ying +6 more
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Research advances of cell autophagy in focal segmental glomerulosclerosis
Linchuang shenzangbing zazhiAs a clinical pathological syndrome, focal segmental glomerulosclerosis （FSGS） is characterized by focal glomerulosclerosis, disappearance of podocyte processes and massive proteinuria. Current researches have confirmed that foot cell injury is a central
Min Zhang, Yan Mi, Cai-li Wang
doaj +1 more source
mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Disease Models & Mechanisms, 2019 Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown +8 more
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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. [PDF]
PLoS Pathogens, 2017 Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Sharon K Kuss-Duerkop +13 more
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
eLife, 2021 The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function.
Maren Heimhalt +15 more
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Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. [PDF]
, 2018 Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown.
Fox, Alexandra Lucienne +5 more
core +2 more sources
PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation [PDF]
Science Signaling, 2014 A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions.
Ashley M, Mackey +4 more
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Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
PLoS Biology, 2022 Mechanistic target of rapamycin complex I (mTORC1) is central to cellular metabolic regulation. mTORC1 phosphorylates a myriad of substrates, but how different substrate specificity is conferred on mTORC1 by different conditions remains poorly defined ...
Kristina Li +5 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The yin yang of sunitinib: One drug, two doses, and multiple outcomes
Molecular & Cellular Oncology, 2017 Our recent work showed that sunitinib exerts dual effect on cancer cells in different dose ranges. In clinically relevant doses, cancer cells tolerate sunitinb cytotoxicity by upregulating pro-survival MCL-1 and activating mTORC1 signaling. Inhibition of
Mohamed Elgendy
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