A predicted two to tango interaction between MUC1 and SOX2: a unique opportunity to target cancer stem cells [PDF]
World Cancer Research Journal, 2022 Objective: Cancer stem cell (CSC) genes are emerging as cancer therapeutic targets. MUC1 is a cell surface-associated glycoprotein that is aberrantly over‐expressed in >60% of human cancers including breast cancer.
A. Dutta, S. Paul
doaj +1 more source
Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo. [PDF]
PLoS ONE, 2012 MUC1 transgenic (MUC1.Tg) mice have widely been used as model recipients of cancer immunotherapy with MUC1. Although MUC1.Tg mice have previously been shown to be immunologically tolerant to MUC1, the involvement of regulatory T (Treg) cells in this ...
Daisuke Sugiura +6 more
doaj +1 more source
Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells. [PDF]
PLoS ONE, 2018 Muc1 is one of the most studied tumor antigens. However, antibodies or antibody-toxin conjugates against Muc1 have not shown significant efficacy for tumors with Muc1 overexpression.
Yumei Li +8 more
doaj +1 more source
MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA. [PDF]
PLoS ONE, 2016 Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The MUC1 gene encodes MUC1-TM, a signal-transducing trans-membrane protein highly expressed in human ...
Michael Chalick +12 more
doaj +1 more source
The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. [PDF]
PLoS ONE, 2012 MUC1 is a large transmembrane glycoprotein and oncogene expressed by epithelial cells and overexpressed and underglycosylated in cancer cells. The MUC1 cytoplasmic subunit (MUC1-C) can translocate to the nucleus and regulate gene expression.
Priyadarsini Kumar +5 more
doaj +1 more source
Suppression of MUC1-Overexpressing Tumors by a Novel MUC1/CD3 Bispecific Antibody
Antibodies, 2023 Mucin1 (MUC1) is abnormally glycosylated and overexpressed in a variety of epithelial cancers and plays a critical role in tumor progression. MUC1 has received remark attention as an oncogenic molecule and is considered a valuable tumor target for ...
Jun Fang, Shifa Lai, Haoyang Yu, Lan Ma
doaj +1 more source
Cell surface-associated anti-MUC1-derived signal peptide antibodies: implications for cancer diagnostics and therapy. [PDF]
PLoS ONE, 2014 The MUC1 tumor associated antigen is highly expressed on a range of tumors. Its broad distribution on primary tumors and metastases renders it an attractive target for immunotherapy. After synthesis MUC1 is cleaved, yielding a large soluble extracellular
Riva Kovjazin +4 more
doaj +1 more source
MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. [PDF]
PLoS ONE, 2012 BACKGROUND:MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways.
Sulagna Banerjee +7 more
doaj +1 more source
Cell Death and Disease, 2022 Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets mitochondria to attenuate drug-induced apoptosis.
Quanfu Li +11 more
doaj +1 more source
Indian Journal of Allergy Asthma and Immunology, 2021 BACKGROUND: Asthma is a chronic disease that affects large number of people worldwide. In urban areas, asthmatic people are getting exposed to pigeon antigen (droppings and feathers) around the workplace and domestic areas.
Anil Kumar Mavi +5 more
doaj +1 more source