Results 81 to 90 of about 20,473 (133)

MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer

Biomedicines
Patients with pancreatic neuroendocrine tumors (pNETs) have limited access to effective targeted agents and invariably succumb to progressive disease. MUC1-C is a druggable oncogenic protein linked to driving pan-cancers. There is no known involvement of
Hiroki Ozawa, Naoki Haratake, Ayako Nakashoji, Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Keisuke Shigeta, Atsushi Fushimi, Kazumasa Fukuda, Yohei Masugi, Ryo Yamaguchi, Minoru Kitago, Hirofumi Kawakubo, Yuko Kitagawa, Donald Kufe   +14 more
doaj   +1 more source

Activation of APOBEC3 cytidine deaminases and endogenous retroviruses is integrated by MUC1-C in NSCLC cells

Cell Death Discovery
The APOBEC3 (A3) genes encoding cytidine deaminases evolved in mammals to restrict retroviral replication. The MUC1 gene appeared in mammals to protect barrier tissues from viral infections.
Naoki Haratake, Shinkichi Takamori, Hideko Isozaki, Keisuke Shigeta, Chie Kikutake, Hiroki Ozawa, Atrayee Bhattacharya, Ayako Nakashoji, Mikita Suyama, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Atsushi Osoegawa, Aaron N. Hata, Donald Kufe   +13 more
doaj   +1 more source

Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection

iScience
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia ...
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum   +6 more
doaj   +1 more source

Evolution of the MUC1 gene in eutherian mammals as an adaptation responsible for the increasing incidence of cancer in humans. [PDF]

Biochim Biophys Acta Rev Cancer
Kufe DW.
europepmc   +1 more source

Tumour-Associated MUC1 Exerts Multiple Effects on Cholesterol and Lipid Metabolism-A Potential Pathogenic Effector of Atherosclerosis in Cancer. [PDF]

Int J Mol Sci
Chen Y, Scully M.
europepmc   +1 more source

A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity. [PDF]

JACS Au
Wu Y, Ma W, Jiang Y, Ling Y, Zhou Y, Guo Y, Hong S, Ding F, Zhang J, Li B, Liang H, Wang Z, Li Y, Li T, Cai H.   +14 more
europepmc   +1 more source

DS-3939a: A TA-MUC1-Directed Antibody-Drug Conjugate with Broad Antitumor Activity. [PDF]

Mol Cancer Ther
Takano K, Yukiura M, Takahashi K, Kitamura M, Okuno H, Shiose Y, Honda K, Oyama K, Yamada M, Obuchi W, Kumagai K, Sakurai K, Goto R, Zembutsu A, Kagari T, Abe Y, Agatsuma T.   +16 more
europepmc   +1 more source

Clinical Significance of Mucin Signatures in Inflammatory Bowel Diseases: A Systematic Review of Their Expression Patterns, Polymorphisms, and Post-translational Modifications. [PDF]

Inflamm Bowel Dis
Arras W, Oosterlinck B, Gassman J, De Man JG, Jauregui-Amezaga A, De Winter BY, Smet A.   +6 more
europepmc   +1 more source

MUC1 peptide-loaded dendritic cell vaccine boosts antitumor immunity in pancreatic cancer. [PDF]

Front Immunol
Xie H, Yang W, Chen H, Zhang Z, Zhao Z, Jin Y, Fan S, Yang Z.   +7 more
europepmc   +1 more source

miRNA‑29a inhibits the proliferation of HUVECs by regulating the ITGB1/β‑catenin/c‑Myc pathway. [PDF]

Mol Med Rep
Sun Q, Chen W, Zhang S, Zhong X, Wu Y, Qian Y, Zhu L, Zhang T, Li W.   +8 more
europepmc   +1 more source