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Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull +7 more
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Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein [PDF]
The oncogenic MUC1-C subunit is aberrantly overexpressed in most human breast cancers by mechanisms that are not well understood. The present studies demonstrate that stimulation of non- malignant MCF-10A cells with epidermal growth factor (EGF) or ...
Jin, Caining +4 more
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The intestinal epithelium surface is covered by a layer of mucus that harbors a complex and dynamic population of bacteria termed gut microbiota. In particular, some gut bacteria have the ability to degrade the mucin glycan for nutritional sources ...
Mingfang Pan +3 more
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Apocrine glands in the eyelid of primates contribute to the ocular host defense [PDF]
Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon.
Stoeckelhuber, B. M. +2 more
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Breast Cancer Vaccine: Are We There Yet? [PDF]
In lieu of an abstract, here is the article\u27s first paragraph: Breast cancer is the most fatal form of cancer for female population worldwide. National Cancer Institute (NCI) estimates 226,870 females and 2,190 males to be diagnosed with breast cancer
Chablani, Lipika
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Introduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients.
Fei Yang +4 more
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In the past three decades, a significant progress has been made in the prevention and treatment of gastric ulcers. The incidence of the disease has decreased, but gastric ulcer is still a medical problem.
Maha B. Salem +5 more
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Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics [PDF]
Mastitis, inflammation of the mammary gland, is the most common and costly disease of dairy cattle in the western world. It is primarily caused by bacteria, with Streptococcus uberis as one of the most prevalent causative agents.
Burchmore, Richard +10 more
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In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD)
Marisa Meloni, Paolo Buratti, Francesco Carriero, Laura Ceriotti VitroScreen, In Vitro Innovation Center, Milan, 20149, ItalyCorrespondence: Laura Ceriotti Via Mosè Bianchi, 103, Milan, 20149, ItalyTel +39 02 89077608Email laura.ceriotti@vitroscreen ...
Meloni M +3 more
doaj
Mucin-1 and its relation to grade, stage and survival in ovarian carcinoma patients
Background Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker assays CA 15–3 and CA 27.29.
Engelstaedter Verena +11 more
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