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The role of mucin 1 in respiratory diseases [PDF]
European Respiratory Review, 2021 Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many pathological processes that occur in the lung. MUC1 is a transmembrane protein mainly expressed by epithelial and hematopoietic cells.
Beatriz Ballester +2 more
doaj +9 more sources
Mucin-1: a promising pan-cancer therapeutic target [PDF]
npj Precision OncologyMucin1 or MUC1 (also known as CD227, EMA, MCD, MAM6, PEM, PUM, KL-6, CA 27.29/CA 15-3) is a highly glycosylated transmembrane mucin family member protein that is overexpressed in various solid or hematological cancers.
Udhayvir Singh Grewal, Razelle Kurzrock
doaj +3 more sources
Plasma Mucin-1 as a Potential Biomarker for Diabetic Peripheral Neuropathy in Type 2 Diabetes [PDF]
BiomoleculesBackground: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes mellitus (T2D) that reduces quality of life and increases the risk of foot ulcers and amputations.
Jae-Hyung Park +6 more
doaj +2 more sources
Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium. [PDF]
Invest Ophthalmol Vis Sci, 2022 To determine the role of transmembrane mucins in blocking fluorescein ingress to the corneal epithelium and its deficiency in contributing to corneal fluorescein punctate staining.A dry eye model was established by extirpating lacrimal and Harderian glands in rabbits to correlate the expression of mucins with fluorescein-stained areas on the corneal ...
Sun YC +5 more
europepmc +3 more sources
Baseline Blood Levels of Mucin-1 Are Associated with Crucial On-Treatment Adverse Outcomes in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Pirfenidone [PDF]
BiomedicinesMucin-1 is a multi-functional glycoprotein expressed by type II alveolocytes and may be detectable in the circulation following pulmonary fibrosis. The prognostic utility of baseline pre-treatment blood levels of mucin-1 in patients with idiopathic ...
Tang-Hsiu Huang +7 more
doaj +2 more sources
Mucin 1 downregulation decreases the anti-tumor effects of melanoma vaccine. [PDF]
Ann Transl Med, 2022 Immunotherapy-based approaches are important breakthroughs with potential treatment benefits for melanoma patients. Mucin 1 (MUC1) is significantly upregulated in melanoma relative to normal cells. It has been reported that MUC1 influences cancer cell proliferation, apoptosis, invasion, and metastasis.The study aimed to explore the effect of MUC1 ...
Shi F +6 more
europepmc +3 more sources
, 2021 ABSTRACT Despite extensive research efforts in prostate cancer for the last several decades, the disease remains a leading cause of cancer death in men in the developed world. A typical feature of prostate cancer initiation and progression is the landscape of genetic alterations, which changes the expression patterns of numerous molecules in prostate ...
Kapoor A +5 more
europepmc +3 more sources
PB2485: INVESTIGATING THE EXPRESSION OF MUCIN-1 (MUC-1) DURING ERYTHROID DIFFERENTIATION [PDF]
HemaSphere, 2023 Hammad Hassan +4 more
doaj +2 more sources
Frontiers in Immunology, 2022 The uterine endometrium uniquely regenerates after menses, postpartum, or after breaks in the uterine layer integrity throughout women’s lives. Direct cell–cell contacts ensured by tight and adherens junctions play an important role in endometrial ...
Umida Ganieva +6 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2021 Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity.
Claudia Hill +9 more
doaj +1 more source