Results 31 to 40 of about 29,691,692 (162)
, 2020 The recombinant antibodies RA11 and RA12 detect by western blot a peptide of the Dictyostelium discoideum Mucolipin protein fused to a GST ...
Blanc, Cédric, Zufferey, Madeleine
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TRPML1 as a potential therapeutic target for triple-negative breast cancer: a review
Frontiers in Oncology, 2023 Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer, and effective treatments are urgently needed owing to its poor prognosis.
Ying Pan +6 more
doaj +1 more source
Identification of the Penta-EF-hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1 [PDF]
Journal of Biological Chemistry, 2009 Loss of function mutations in mucolipin-1 (MCOLN1) have been linked to mucolipidosis type IV (MLIV), a recessive lysosomal storage disease characterized by severe neurological and ophthalmological abnormalities. MCOLN1 is an ion channel that regulates membrane transport along the endolysosomal pathway.
Silvia, Vergarajauregui +2 more
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Molecular Therapy: Nucleic Acids, 2021 Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD), whereby accumulation of damaged mitochondria in conjunction with impaired mitophagy contributes to neurodegeneration.
Lu Zhang +7 more
doaj +1 more source
Structural basis for PtdInsP2-mediated human TRPML1 regulation
Nature Communications, 2018 Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate ...
Michael Fine +2 more
doaj +1 more source
Abnormal Lysosomal Positioning and Small Extracellular Vesicle Secretion in Arterial Stiffening and Calcification of Mice Lacking Mucolipin 1 Gene [PDF]
International Journal of Molecular Sciences, 2020 Recent studies have shown that arterial medial calcification is mediated by abnormal release of exosomes/small extracellular vesicles from vascular smooth muscle cells (VSMCs) and that small extracellular vesicle (sEV) secretion from cells is associated with lysosome activity.
Bhat, Owais M. +4 more
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Nature Communications, 2023 Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose.
Dengqin Zhong +5 more
doaj +1 more source
Data in Brief, 2023 Retinal degenerative diseases (RDDs) are a diverse group of retinal disorders that cause visual impairment. While RDD prevalence is high, little is known about the molecular mechanisms underlying the pathogenesis within many of these disorders.
Rebecca Cistulli +3 more
doaj +1 more source
Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx [PDF]
Journal of Cell Science, 2016 ABSTRACT Transient receptor potential (TRP) mucolipins (TRPMLs), encoded by the MCOLN genes, are patho-physiologically relevant endo-lysosomal ion channels crucial for membrane trafficking. Several lines of evidence suggest that TRPMLs mediate localised Ca2+ release but their role in Ca2+ signalling is not clear.
Bethan S. Kilpatrick +4 more
openaire +3 more sources
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis [PDF]
Proceedings of the National Academy of Sciences, 2004 Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disease characterized by severe psychomotor retardation, achlorhydria, and ophthalmological abnormalities. Cells from several tissues in MLIV patients accumulate large vacuoles that are presumed to be lysosomes, but whose exact nature remains to be determined.
Sebastian, Treusch +5 more
openaire +2 more sources