TRPM Channels in Human Diseases
Cells, 2020 The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions ...
Ivanka Jimenez +7 more
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Function and pharmacology of TRPM cation channels [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2005 The physiological function and cellular role of some members of the TRPM family are poorly understood and still mysterious. Melastatin, the founding member of the TRPM group, is the most prominent example of the mysteries involved in understanding TRP channel function.
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels. [PDF]
PLoS ONE, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Thomas Hofmann +5 more
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Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. [PDF]
PLoS ONE, 2010 Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney ...
Takayuki Teramoto +7 more
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The Promotion of Gonadal Cell Divisions by the Caenorhabditis elegans TRPM Cation Channel GON-2 Is Antagonized by GEM-4 Copine [PDF]
Genetics, 2003 Abstract The initiation of postembryonic cell divisions by the gonadal precursors of C. elegans requires the activity of gon-2. gon-2 encodes a predicted cation channel (GON-2) of the TRPM subfamily of TRP proteins and is likely to mediate the influx of Ca2+ and/or Mg2+.
Diane L, Church, Eric J, Lambie
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TRP channels: Role in neurodegenerative diseases and therapeutic targets
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
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TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
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Selenium Modulates Oxidative Stress‐Induced
Basic & Clinical Pharmacology & Toxicology, 2012 AbstractIt has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood.
Özgül, Cemil +5 more
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Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens. [PDF]
PLoS ONE, 2015 TRP (Transient Receptor Potential) cation channels of the TRPM subfamily have been found to be critically important for the regulation of Mg2+ homeostasis in both protostomes (e.g., the nematode, C. elegans, and the insect, D.
Eric J Lambie +3 more
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Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
Frontiers in Physiology, 2021 Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes +4 more
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