Results 31 to 40 of about 1,001,638 (111)

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development [PDF]

, 2010
SummaryTRPM channels have emerged as key mediators of diverse physiological functions. However, the ionic permeability relevant to physiological function in vivo remains unclear for most members.
Hanneke Okkenhaug, Georgiev, P., Drews, Anna, Melanie Flick, Lambert, S., Sachar Lambert, Raghu, P., Johannes Oberwinkler, Martel, Cecile, Carta, Valentina, Oberwinkler, J., Padinjat Raghu, Drews, A., Wright, D., David Wright, Cecile Martel, Raghu, Padinjat, Oberwinkler, Johannes, Martel, C., Valentina Carta, Okkenhaug, Hanneke, Plamen Georgiev, Anna Drews, Georgiev, Plamen, Flick, M., Wright, David, Carta, V., Flick, Melanie, Lambert, Sachar, Okkenhaug, H.   +29 more
core   +1 more source

Multimodal targets of (‐)‐α‐thujone mediating avoidance behavior of a stored‐products pest, Tribolium castaneum, in response to irritant stimuli

Pest Management Science, Volume 82, Issue 10, Page 9592-9598, October 2026.
We identified four kinds of target molecules against (‐)‐α‐thujone associating avoidance behavior in Tribolium castaneum, indicating multimodality. Abstract BACKGROUND The reciprocal evolutionary processes among phytophagous insects and host plants involve host shift in the herbivorous insects in response to defense chemicals, such as plant‐derived ...
Kenji Shimomura, Yuto Suzuki, Soshi Ino, Takehito Terajima, Motohiro Tomizawa   +4 more
wiley   +1 more source

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses

Frontiers in Immunology, 2018
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni, Maria Beatrice Morelli, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Oliviero Marinelli, Angela Santoni, Angela Santoni   +9 more
doaj   +1 more source

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +1 more source

Functions of TRPs in retinal tissue in physiological and pathological conditions

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +1 more source

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

eLife, 2018
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang, Balázs Tóth, Andras Szollosi, Jue Chen, László Csanády   +4 more
doaj   +1 more source

Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb‐Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim The kidney thick ascending limb (TAL) plays a key role in the transport of sodium, chloride, potassium, calcium, and magnesium. Bartter syndrome is a hypokalemic, salt‐losing tubulopathy caused by impaired TAL function. Pathogenic variants in SLC12A1 or KCNJ1 cause antenatal Bartter syndrome, and variants in CLCNKB result in classical ...
Marleen L. A. Kortenoeven, Milos Bogdanovic, Ida Appel, Karsten Skjødt, Ernst‐Martin Fuchtbauer, Kirsten Madsen, Lars Lund, Régine Chambrey, Dominique Eladari, R. Todd Alexander, Christian A. Hübner, J. Christopher Hennings, Henrik Dimke   +12 more
wiley   +1 more source

Conservation of the cooling agent binding pocket within the TRPM subfamily

eLife
Transient receptor potential (TRP) channels are a large and diverse family of tetrameric cation-selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or cooling agents,
Kate Huffer, Matthew CS Denley, Elisabeth V Oskoui, Kenton J Swartz   +3 more
doaj   +1 more source

Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats [PDF]

, 2008
<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p> <p><b>Methods:</b> ...
McCabe, C., Lees, K.R., Muir, K., Lecrux, C., Weir, C.J., Mullin, J., Touzani, O., Macrae, I.M., Gallagher, L.   +8 more
core   +1 more source