Results 51 to 60 of about 5,720 (153)
3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines [PDF]
, 2018 3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to ...
Biebermann, Heike +7 more
core +2 more sources
FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure [PDF]
, 2018 Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, TRPM and TRPV subfamilies have
Diez Bello, Raquel +6 more
core +2 more sources
Heart Failure: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 3, March 2026.This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source
The role of TRP proteins in mast cells
Frontiers in Immunology, 2012 TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel +2 more
doaj +1 more source
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Expression and function of transient receptor potential channels in the female bovine reproductive tract [PDF]
, 2016 © 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions.
Atkin, Stephen L. +3 more
core +2 more sources
Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells [PDF]
, 2017 Thiazides block Na+ reabsorption while enhancing Ca2 + reabsorption in the kidney. As previously demonstrated in immortalized mouse DCT (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, which increased Ca2 ...
Shrier, Alvin +2 more
core +1 more source
The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury
Computational and Structural Biotechnology Journal, 2015 Excitotoxicity involves the excessive release of glutamate from presynaptic nerve terminals and from reversal of astrocytic glutamate uptake, when there is excessive neuronal depolarization.
Denson G. Fujikawa
doaj +1 more source
Reproduction in Domestic Animals, Volume 61, Issue 3, March 2026.ABSTRACT This study aimed to evaluate the effects of probiotic supplementation on bovine sperm cryopreservation by assessing post‐thaw spermatological and biochemical parameters. Twenty‐four ejaculations were collected from four Simmental bulls using the artificial vagina method.
Ali Doğan Ömür +11 more
wiley +1 more source