Results 51 to 60 of about 1,001,638 (111)

Transient receptor potential cation channels in disease [PDF]

, 2007
The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations.
Owsianik, Grzegorz, Voets, Thomas, Nilius, Bernd, Peters, John A.   +3 more
core   +1 more source

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Identification and functional characterisation of a class on non-selective cation channels in Saccharomyces cerevisiae. [PDF]

, 2009
Na⁺ accumulation is a significant component in salt toxicity in plants. Although many proteins that facilitate Na⁺ flux have been identified in plants, investigations aimed at identifying the initial mechanism of Na⁺ entry into plants have failed.
Carter, Scott Anthony William
core  

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster, Noy Midler, Ori Shine, Dekel Rosenfeld   +3 more
wiley   +1 more source

Probiotic Supplementation as an Alternative to Antibiotics in Bovine Sperm Cryopreservation: Effects on Motility, Oxidative Stress and Apoptosis

Reproduction in Domestic Animals, Volume 61, Issue 3, March 2026.
ABSTRACT This study aimed to evaluate the effects of probiotic supplementation on bovine sperm cryopreservation by assessing post‐thaw spermatological and biochemical parameters. Twenty‐four ejaculations were collected from four Simmental bulls using the artificial vagina method.
Ali Doğan Ömür, Demet Çelebi, Serkan Ali Akarsu, Betül Apaydin Yildirim, Gamze Uçak, Tutku Can Acisu, Mehmet Akif Aydin, Sümeyye Başer, Özgür Çelebi, Recep Hakkı Koca, Gözde Arkali, Tarique Hussain   +11 more
wiley   +1 more source

Alignment of human TRPM channels 1-8 amino acid sequences

, 2019
Supplementary Figure 1:Alignment of human TRPM channels 1-8 amino acid sequences (UniProt accession codes Q7Z4N2, O94759, Q9HCF6, Q8TD43, Q9NZQ8, Q9BX84, Q96QT4 and Q7Z2W7, respectively), with sequences for the cryo-EM structures of N.
John Sayer (6654227)
core   +1 more source

From cardiac cation channels to the molecular dissection of the transient receptor potential channel TRPM4 [PDF]

, 2006
In 2006, we celebrate not only the milestone paper on the patch-clamp technique [14] but also the publication of the first single-channel measurements in cardiac cells revealing a Ca(2+)-activated, nonselective cation channel [6]. Considerable effort has
Vennekens, Rudi, Nilius, Bernd
core   +1 more source