Results 61 to 70 of about 1,001,638 (111)

TRPM8 Regulates Mitochondrial Ca2+‐Dynamics, Temperature and Endoplasmic Reticulum‐Mitochondrial Contact Points in T Cell

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT TRPM8 is a cold temperature‐sensitive and non‐selective Ca2+‐channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub‐cellular compartments.
Tusar Kanta Acharya, Shamit Kumar, Tejas Pravin Rokade, Parnasree Mahapatra, Young Tae Chang, Chandan Goswami   +5 more
wiley   +1 more source

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987)   +14 more
core   +2 more sources

Transient receptor potential channels in Flaviviridae infection: A comprehensive review

Channels
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang, Xiaoqiang Yao, Chang-Bo Zheng   +2 more
doaj   +1 more source

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, Volume 111, Issue 2, Page 449-463, 1 February 2026.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source

The selectivity filter of the cation channel TRPM4 [PDF]

, 2005
Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close homologue, TRPM5, are the only two members of the large transient receptor potential superfamily of cation channels that are impermeable to Ca(2+). In this study, we located
Zhu, Michael X., Owsianik, Grzegorz, Voets, Thomas, Nilius, Bernd, Prenen, Jean, Wang, Chunbo, Janssens, Annelies   +6 more
core   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

TRPM channels in human cancers: regulatory mechanism and therapeutic prospects

The transient receptor potential melastatin (TRPM) channel family has been previously implicated in various diseases, including those related to temperature sensing, cardiovascular health, and neurodegeneration.
Rui Zhang, Jingfeng Tang, Shi Li, Xin Zhang, Dong Guo, Qinfeng Liu, Xing-Zhen Chen, Mengyu Hu, Shuai Xiao, Hao Lyu, Cefan Zhou   +10 more
core   +1 more source

Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels

Human Mutation, Volume 2026, Issue 1, 2026.
Background Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly characterized. Methods We curated a comprehensive compendium of 522 TRP‐related genes from MSigDB, KEGG, and GeneCards.
Runfeng Sun, Long Zhu, Zhichao Lu, Ziheng Wang, Suyin Feng, Jingwei Zhao, Lin Zhang   +6 more
wiley   +1 more source

Molecular and evolutionary determinants of cation permeation in members of the TRPM-subfamily

, 2011
Hypomagnesiämie mit sekundärer Hypocalciämie (HSH) ist ein Krankheitsbild, das sich durch Muskelkrämpfe und neurologische Schädigungen aufgrund des Magnesiummangels äußert. Verschiedene Punktmutationen im Gen des TRPM6-Proteins werden als Ursache für die
Wäring, Janine
core   +1 more source

Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress

BMC Genomics
Background Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian, Qiaoling Yu, Jun Zhang, Yaoyao Han, Xi Xie, Dongfa Zhu   +5 more
doaj   +1 more source