Results 71 to 80 of about 5,720 (153)

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles [PDF]

, 2016
Purpose: Activation of the transient receptor potential channels, TRPC6, TRPM4, and TRPP1 (PKD2), has been shown to contribute to the myogenic constriction of cerebral arteries.
Curtis, Tim M., Dash, Durga P, Fernández, José A, McGahon, Mary K, McGeown, J. Graham, McKee, Jon, Simpson, David A, Zholos, Alex V   +7 more
core   +1 more source

Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins [PDF]

, 2018
Cold-inducible RNA-binding protein (CIRP), RNA-binding motif protein 3 (RBM3) and serine and arginine rich splicing factor 5 (SRSF5) are RNA-binding proteins that are transcriptionally upregulated in response to moderately low temperatures and a variety ...
Fujita Jun, Fujita Takanori, Higashitsuji Hiroaki, Itoh Katsuhiko, Liu Yu, Nishiyama Hiroyuki, Shibasaki Koji, 西山 博之   +7 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Transient receptor potential channels in Flaviviridae infection: A comprehensive review

Channels
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang, Xiaoqiang Yao, Chang-Bo Zheng   +2 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, Volume 19, Issue 10, Page 2905-2920, October 2025.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]

, 2013
Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau, Gaudet, Rachelle, Perálvarez-Marín, Alex   +2 more
core   +1 more source

Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress

BMC Genomics
Background Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian, Qiaoling Yu, Jun Zhang, Yaoyao Han, Xi Xie, Dongfa Zhu   +5 more
doaj   +1 more source

Reactive Oxygen Species‐Mediated TRPM2 Activation Facilitates Phagocytosis of Macrophages to Reverse Profibrotic Phenotype

Liver International, Volume 45, Issue 10, October 2025.
ABSTRACT Background and Aims Macrophages play plastic roles during fibrogenesis and fibrosis regression. Phagocytosis is considered a trigger for shifting macrophages from a profibrotic phenotype to a restorative phenotype. However, the underlying mechanism by which macrophages enhance phagocytosis remains unclear.
Shaoying Zhang, Fanfan Liang, Dan Wan, Chongyu Zhang, Yinggang Zhang, Xurui Zhang, Na Huang, Keping Feng, Xiao Liang, Ni Guo, Chen Zhang, Zhe Zhou, Yuehua Li, Jing Geng, Pengfei Liu, Guangyao Kong, Shemin Lu, Zongfang Li   +17 more
wiley   +1 more source

Tonantzitlolone is a Nanomolar Potency Activator of TRPC1/4/5 Channels. [PDF]

, 2018
BACKGROUND AND PURPOSE The diterpene ester tonantzitlonone (TZL) is a natural product which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells.
Abramowitz, Akbulut, Alexander, Alexander, Alexander, Beech, Busch, Busch, Camacho Londono, Caropreso, Carson, Curtis, Dietrich, Fan, Gaunt, Harding, Jasper, Just, Ludlow, Muraki, Naylor, Pfeffer, Ratnayake, Rubaiy, Rubaiy, Rubaiy, Rubaiy, Sourbier, Sourbier, Storch, Vinayagam, Westlund, Wu   +32 more
core   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, Volume 3, Issue 3, September 2025.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source