Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens
CellsTRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca2+) channel.
Yuefang Zhou +7 more
doaj +1 more source
On the putative role of transient receptor potential cation channels in asthma
, 2009 The mammalian transient receptor potential (TRP) superfamily consists of 28 mammalian TRP cation channels, which can be subdivided into six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ...
Vennekens, Rudi +5 more
core +1 more source
Pharmacology of vanilloid transient receptor potential cation channels [PDF]
, 2009 Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ...
Appendino, Giovanni +2 more
core +1 more source
Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels [PDF]
, 2014 Whilst fertilizing capacity depends upon a K+ conductance G? that allows the spermatozoon membrane potential Vm to be held at a negative value, the characteristics of this conductance in human sperm are virtually unknown.
Barratt, C.L.R.; id_orcid +8 more
core +1 more source
Molecular determinants of permeation through the cation channel TRPM6 [PDF]
, 2007 Contains fulltext : 52400.pdf (Publisher’s version ) (Open Access)TRPM6 and its closest relative TRPM7 are members of the Transient Receptor Potential Melastatin (TRPM) subfamily of cation channels and are known to be Mg2+ permeable. By
Berg, D.T.M. van den +13 more
core +2 more sources
Extracellular blockade of K(+) channels by TEA : results from molecular dynamics simulations of the KcsA channel [PDF]
, 2001 TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to ...
Simon Bernèche +5 more
core +1 more source
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
core
Pharmacology of transient receptor potential melastatin channels in the vasculature.
, 2010 Mammalian transient receptor potential melastatin (TRPM) non-selective cation channels, the largest TRP subfamily, are widely expressed in excitable and non-excitable cells where they perform diverse functions ranging from detection of cold, taste ...
Zholos, Alexander
core +1 more source
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]
, 2009 In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N. +5 more
core +1 more source