Results 41 to 50 of about 1,001,638 (111)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, Volume 16, Issue 8, Page 1477-1490, August 2026.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The role of TRP proteins in mast cells

Frontiers in Immunology, 2012
TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel, Julia eAlmering, Volodymyr eTsvilovskyy   +2 more
doaj   +1 more source

Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant

Experimental Physiology, Volume 111, Issue 7, Page 3294-3309, 1 July 2026.
Abstract TRPM4 is a calcium‐activated, voltage‐modulated, non‐selective cation channel expressed in various tissues, including the heart. In 2016, we reported on a large French family with progressive heart block type I carrying the variant TRPM4 p.I376T.
Sabrina Guichard, Emanuele di Lorenzo, Dominic Schneiter, Maria Essers, Prakash Arullampalam, Jean‐Sébastien Rougier, Hugues Abriel   +6 more
wiley   +1 more source

Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging

Aging Cell, Volume 25, Issue 6, June 2026.
This review positions magnesium as a central bioenergetic checkpoint that orchestrates mitochondrial function and metabolic resilience. By defining the functional ATP pool and stabilizing mitochondrial performance, magnesium homeostasis serves as a mechanistic link between renal handling, metabolic disease, and the aging process.
Chien‐Wei Huang, Chen‐Yueh Wen, Andy P. Tsai, Boyang Wang, Kuan‐Hao Tsui, Yu‐Juei Hsu, Chia‐Jung Li   +6 more
wiley   +1 more source

The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury

Computational and Structural Biotechnology Journal, 2015
Excitotoxicity involves the excessive release of glutamate from presynaptic nerve terminals and from reversal of astrocytic glutamate uptake, when there is excessive neuronal depolarization.
Denson G. Fujikawa
doaj   +1 more source

Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng, Ning Liang, Pingping Hu, Yingying Zhang, Jun Wang, Zhong Lu, Kai Guan, Guodong Deng, Jiandong Zhang   +8 more
wiley   +1 more source

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam

International Journal for Parasitology: Drugs and Drug Resistance
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues ...
Claudia M. Rohr, Paul McCusker, Marc Kaethner, Rebecca Armstrong, Emily Robb, Sang-Kyu Park, Daniel J. Sprague, Aaron G. Maule, Mostafa Zamanian, Britta Lundström-Stadelmann, John D. Chan, Jonathan S. Marchant   +11 more
doaj   +1 more source

Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex

Frontiers in Cellular Neuroscience, 2017
Temporal lobe epilepsy is characterized by recurrent seizures in one or both temporal lobes of the brain; some in vitro models show that epileptiform discharges initiate in entorhinal layer V neurons and then spread into other areas of the temporal lobe.
Eric C. Lin, Crescent L. Combe, Sonia Gasparini, Sonia Gasparini   +3 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, Volume 600, Issue 6, Page 894-909, March 2026.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source