Nonsteroidal Anti-Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies. [PDF]
ChemMedChemBeyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Laghetti P +4 more
europepmc +2 more sources
Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]
, 2017 Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie +7 more
core +1 more source
Decreased TRPM7 inhibits activities and induces apotosis of bladder cancer cells via ERK1/2 pathway [PDF]
, 2016 published_or_final_versio
Cao, R +8 more
core +1 more source
Frontiers in Immunology, 2018 Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni +9 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2015/16:Voltage-gated ion channels [PDF]
, 2015 The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
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core +4 more sources
Functions of TRPs in retinal tissue in physiological and pathological conditions
Frontiers in Molecular NeuroscienceThe Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento +10 more
doaj +1 more source
Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng +8 more
wiley +1 more source
Microglia in Alzheimer's disease: a role for ion channels [PDF]
, 2018 Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40 million people worldwide. Classically, the disease has been characterized by the neuropathological hallmarks of aggregated extracellular amyloid-β and ...
Dallas, Mark L. +4 more
core +2 more sources
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation
eLife, 2018 Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang +4 more
doaj +1 more source
The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]
, 2019 Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core