Results 21 to 30 of about 5,720 (153)

Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats

Cellular Physiology and Biochemistry, 2013
Background: Pulmonary hypertension (PH) is characterized by profound vascular remodeling and alterations in Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Multiple transient receptor potential melastatin-related (TRPM) subtypes have
Xiao-Ru Liu, Qing Liu, Gai-Ying Chen, Ying Hu, James S.K. Sham, Mo-Jun Lin   +5 more
doaj   +1 more source

TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation.

PLoS ONE, 2012
TRPM2, a highly Ca(2+)-permeable member of the transient receptor potential melastatin-related (TRPM) family of cation channels, is expressed in cells of the immune system. We demonstrate firstly that TRPM2 cation channels on T cells critically influence
Nico Melzer, Gordon Hicking, Kerstin Göbel, Heinz Wiendl   +3 more
doaj   +1 more source

TRP Channels Role in Pain Associated With Neurodegenerative Diseases

Frontiers in Neuroscience, 2020
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain.
Milena Duitama, Viviana Vargas-López, Zulma Casas, Sonia L. Albarracin, Jhon-Jairo Sutachan, Yolima P. Torres   +5 more
doaj   +1 more source

Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

Life, 2021
The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions.
Andras Szollosi
doaj   +1 more source

Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]

, 2016
Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T., Callera, Glaucia E., He, Ying, Ryazanov, Alexey G., Ryazanov, Lillia V., Shrier, Alvin, Stewart, Duncan J., Touyz, Rhian, Yogi, Alvaro, Zhai, Alexander   +9 more
core   +1 more source

Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): We aimed to investigate the levels of transient receptor potential melastatin (TRPM) gene expression, and the antioxidant and histopathologic effect of thymoquinone (Tmq) in the hepatic I/R rat model.Materials and Methods: Fifty Wistar rats
Kerem Caglar, Recep Dokuyucu, Gokhan Agturk, Cemil Tumer, Okan Tutuk, Hatice Dogan Gocmen, Hasan Gokce, Zeynel Abidin Tas, Oguzhan Ozcan, Bulent Gogebakan   +9 more
doaj   +1 more source

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

British Journal of Pharmacology, 2014
Background and PurposeTransient receptor potential melastatin 3 (TRPM3) proteins form non‐selective but calcium‐permeable membrane channels, rapidly activated by extracellular application of the steroid pregnenolone sulphate and the dihydropyridine nifedipine.
Drews, A, Mohr, F, Rizun, O, Wagner, T F J, Dembla, S, Rudolph, S, Lambert, S, Konrad, M, Philipp, S E, Behrendt, M, Marchais-Oberwinkler, S, Covey, D F, Oberwinkler, J   +12 more
openaire   +2 more sources

Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats [PDF]

, 2008
<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p> <p><b>Methods:</b> ...
Gallagher, L., Lecrux, C., Lees, K.R., Macrae, I.M., McCabe, C., Muir, K., Mullin, J., Touzani, O., Weir, C.J.   +8 more
core   +1 more source

Calcium signaling in oomycetes: an evolutionary perspective [PDF]

, 2016
Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being ...
Mackrill, John J., Zheng, Limian
core   +4 more sources

The essential roles of metal ions in insect homeostasis and physiology [PDF]

, 2017
Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
core   +1 more source