Results 11 to 20 of about 1,001,638 (111)
PLoS ONE, 2012 TRPM2, a highly Ca(2+)-permeable member of the transient receptor potential melastatin-related (TRPM) family of cation channels, is expressed in cells of the immune system. We demonstrate firstly that TRPM2 cation channels on T cells critically influence
Nico Melzer +3 more
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Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats
Cellular Physiology and Biochemistry, 2013 Background: Pulmonary hypertension (PH) is characterized by profound vascular remodeling and alterations in Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Multiple transient receptor potential melastatin-related (TRPM) subtypes have
Xiao-Ru Liu +5 more
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A Rare Cause of Seizures: Hypomagnesemia Type 1
Revista Portuguesa de Nefrologia e Hipertensão, 2023 Hypomagnesemia type I is a rare autosomal recessive disorder characterized by severe hypomagnesemia, often accompanied by hypocalcemia. This disease is caused by mutations in the TRPM6 gene (which encodes the respective channel), leading to reduced ...
Inês Gameiro +5 more
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On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications
, 2022 The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and
González-Muñiz, Rosario +4 more
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Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]
, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner +35 more
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TRP Channels Role in Pain Associated With Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain.
Milena Duitama +5 more
doaj +1 more source
British Journal of Pharmacology, 2014 Background and PurposeTransient receptor potential melastatin 3 (TRPM3) proteins form non‐selective but calcium‐permeable membrane channels, rapidly activated by extracellular application of the steroid pregnenolone sulphate and the dihydropyridine nifedipine.
Drews, A +12 more
openaire +2 more sources
Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): We aimed to investigate the levels of transient receptor potential melastatin (TRPM) gene expression, and the antioxidant and histopathologic effect of thymoquinone (Tmq) in the hepatic I/R rat model.Materials and Methods: Fifty Wistar rats
Kerem Caglar +9 more
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Life, 2021 The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions.
Andras Szollosi
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TRP Channels in Angiogenesis and Other Endothelial Functions
Frontiers in Physiology, 2018 Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors.
Tarik Smani +7 more
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