Results 51 to 60 of about 608,623 (303)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Intestinal damage precedes mucosal immune dysfunction in SIV infection

, 2018
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation.
Hu, Shiu-Lok, Hensley-McBain, Tiffany, Agricola, Brian, Miller, Charlene J, Estes, Jacob D, Klatt, Nichole R, Zevin, Alexander S, Smedley, Jeremy, Gile, Jillian, Reeves, R Keith, Cameron, Mark, Burgener, Adam D, Manuzak, Jennifer A, Polacino, Patricia, Keele, Brandon F, Berard, Alicia R, Zevin, AS, Hensley-McBain, T, Cameron, M, Manuzak, JA, Gile, J, Berard, AR, Hu, S-L, Agricola, B, Polacino, P, Miller, CJ   +25 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma

Frontiers in Surgery, 2016
Aim To identify and characterize cancer stem cells (CSC) in moderately differentiated buccal mucosa squamous cell carcinoma (MDBMSCC). Methods 4μm-thick formalin-fixed paraffin-embedded MDBMSCC samples from six patients underwent 3,3-diaminobenzidine ...
Helen H Yu, Therese Featherston, Swee T Tan, Alice Margaret Chibnall, Helen D Brasch, Paul F Davis, Tinte Itinteang   +6 more
doaj   +1 more source

PO and ID BCG vaccination in humans induce distinct mucosal and systemic immune responses and CD4(+) T cell transcriptomal molecular signatures [PDF]

, 2017
Protective efficacy of Bacillus Calmette-Guérin (BCG) may be affected by the methods and routes of vaccine administration. We have studied the safety and immunogenicity of oral (PO) and/or intradermal (ID) administration of BCG in healthy human subjects.
Kaplan, C., Andersen, P.L., Schlesinger, L.S., Dube, T.J., Brusic, V., Xia, M., Tennant, J., Matuschak, G., Blazevic, A., Hoft, D.F., Zhang, G.L., Hill, H., C Kaplan, A Blazevic, T J Dube, D F Hoft, P L Andersen, G L Zhang, M Xia, J Tennant, G Matuschak, H Hill, V Brusic, L S Schlesinger   +23 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Diverse functions of mucosal resident memory T cells [PDF]

, 2015
Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during
Kimberly Sue Schluns, Sue Schluns, Kimberly, Klonowski, Kim, Kim Klonowski   +3 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The role of sea buckthorn in skin and mucosal health: a review from an anti-inflammatory perspective

Frontiers in Pharmacology
The skin and mucosal barriers serve as essential frontline defenses, protecting against pathogens, environmental insults, and excessive water loss while maintaining physiological homeostasis. Sea buckthorn (Hippophae rhamnoides), a plant long utilized in
Xiayinan Song, Xinyao Sun, Huimin Yuan, Yang Tang, Fengjie Zheng   +4 more
doaj   +1 more source

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

, 2012
Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively.
Hansbro, PM, N J Talley, P M Hansbro, Keely, S, S Keely, Talley, NJ   +5 more
core   +1 more source