Results 41 to 50 of about 608,623 (303)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right Tissues

, 2012
The mucosal immune system exhibits a high degree of anatomic compartmentalization related to the migratory patterns of lymphocytes activated at different mucosal sites.
Holmgren, Jan,, Czerkinsky, Cecil,
core   +1 more source

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]

, 2008
Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki, Korponay-Szabó, Ilma Rita, Korponay-Szabo Ilma R, Lohi, Olli, Ilma R Korponay-Szabo, Katri Haimila, Stenman, Satumarja M., Olli Lohi, Partanen, Jukka, Herbert Wieser, Maki, Markku, Mäki Markku, Lindfors, Katri, Haimila Katri, Paivi Saavalainen, Saavalainen Päivi, Saavalainen, Paivi, Lohi Olli, Stenman, Satumarja M, Partanen Jukka, Kaukinen, Katri, Satumarja M Stenman, Haimila, Katri, Stenman Satumarja M, Wieser Herbert, Katri Kaukinen, Wieser, Herbert, Kaukinen Katri, Korponay-Szabó, Ilma, Katri Lindfors, Jukka Partanen, Lindfors Katri   +31 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Winter, Harland, Szigeti, Reka, Kaplan, Jess L., Harris, R. Alan, Nagy-Szakal, Dorottya, Kellermayer, Richard, Ferry, George D., Opekun, Antone, Bronsky, Jiri, Mir, Sabina A.V., Frank, Eibe   +10 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Role of NKp46+ natural killer cells in house dust mite‐driven asthma

EMBO Molecular Medicine, 2018
House dust mite (HDM)‐allergic asthma is driven by T helper 2 (Th2) lymphocytes, but also innate immune cells control key aspects of the disease. The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has
Eline Haspeslagh, Mary J van Helden, Kim Deswarte, Sofie De Prijck, Justine van Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Human γδ T-Cell Control of Mucosal Immunity and Inflammation

Frontiers in Immunology, 2018
Human γδ T-cells include some of the most common “antigen-specific” cell types in peripheral blood and are enriched yet further at mucosal barrier sites where microbial infection and tumors often originate.
Neil E. McCarthy, Matthias Eberl
doaj   +1 more source

Mucocutaneous findings in patients with cerebral palsy: A cross-sectional observational study

Indian Journal of Paediatric Dermatology, 2020
Introduction: Cerebral palsy (CP) is a condition characterized by abnormal muscle tone or posture and coordination. It is caused due to injury to the immature brain usually at or before birth.
Bhabani STP Singh, Tapaswini Tripathy, Manish Kumar Sahu, Sweta, Bikash Ranjan Kar   +4 more
doaj   +1 more source