Results 31 to 40 of about 608,623 (303)

Mucosal vaccination with outer membrane vesicles derived from Bordetella pertussis reduces nasal bacterial colonization after experimental infection

Frontiers in Immunology
IntroductionWe previously identified Bordetella pertussis-derived outer membrane vesicles (OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we evaluated the efficacy of our vaccine prototype in immunization strategies aimed
E. Rudi, E. Gaillard, D. Bottero, T. Ebensen, C. A. Guzman, Daniela Hozbor   +5 more
doaj   +1 more source

Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitisResearch in the context

EBioMedicine, 2019
Background: Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy.
Shimpei Kasagi, Dandan Wang, Pin Zhang, Peter Zanvit, Hua Chen, Dunfang Zhang, Jia Li, Li Che, Takashi Maruyama, Hiroko Nakatsukasa, Ruiqing Wu, Wenwen Jin, Lingyun Sun, WanJun Chen   +13 more
doaj   +1 more source

Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile

Pharmaceutics, 2022
Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular toxoid vaccines entered Phase III trials and strongly induced toxin-
Jaime Hughes, Carl Aston, Michelle L. Kelly, Ruth Griffin   +3 more
doaj   +1 more source

Nasal and Salivary Mucosal Humoral Immune Response Elicited by mRNA BNT162b2 COVID-19 Vaccine Compared to SARS-CoV-2 Natural Infection

Vaccines, 2021
SARS-CoV-2 antibody assays are crucial in managing the COVID-19 pandemic. Approved mRNA COVID-19 vaccines are well known to induce a serum antibody responses against the spike protein and its RBD.
Mariapia Guerrieri, Beatrice Francavilla, Denise Fiorelli, Marzia Nuccetelli, Francesco Maria Passali, Luca Coppeta, Giuseppina Somma, Sergio Bernardini, Andrea Magrini, Stefano Di Girolamo   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Primary malignant melanoma of the gastric antrum: A case report

Clinical Case Reports, 2021
Primary melanoma of the antrum is a rare and aggressive disease. Diagnosis requires a correlation between the patient's history, tumor histopathology, and immunohistochemistry. Surgery and mutation‐targeted treatments may improve overall survival.
Ahmed I. Younes, Anas Mohamed, Areeba H. Rizvi, Karyn Prenshaw   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The regulation of gut mucosal IgA B-cell responses: recent developments

, 2017
The majority of activated B cells differentiate into IgA plasma cells, with the gut being the largest producer of immunoglobulin in the body. Secretory IgA antibodies have numerous critical functions of which protection against infections and the role ...
N.Y. Lycke, Bemark, Mats,, Lycke, Nils Y,, M. Bemark   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection [PDF]

, 2012
HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms remain unclear.
Lifson, Jeffrey D., Tabb, B, Estes, Jacob D., Ortiz, A M, Haddad, Elias K., Barber, J S, Paiardini, M, Cervasi, Barbara, Tabb, Brian, Klatt, Nichole R., Barber, John S., Yokomizo, Lauren K., Pan, Li, Alter, Galit, Cervasi, B, Paiardini, Mirko, Vinton, Carol L., Harris, Levelle D., Harris, L D, Canary, L A, Alter, G, Belkaid, Yasmine, Sun, Xiaoyong, Yokomizo, L K, Vinton, C L, Hirsch, V M, Klatt, N R, Dang, Q, Ortiz, Alexandra M., Haddad, E K, Silvestri, Guido, Belkaid, Y, Silvestri, G, Brenchley, Jason M., Milner, J D, Pan, L, Canary, Lauren A., Milner, Joshua D., Hirsch, Vanessa M., Brenchley, J M, Dang, Que, Estes, J D, Sun, X, Lifson, J D   +43 more
core   +1 more source