Results 11 to 20 of about 608,623 (303)

Mucosal Adjuvants

Current HIV Research, 2010
The vast majority of pathogens invade the body through or establish infections in the mucosal tissues. Development of vaccines to combat mucosal infections represents a top priority. Mucosal immunization has recently attracted much interest as a means of generating protective immunity against mucosal pathogens.
HARANDI A. M., MEDAGLINI D.
core   +6 more sources

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]

, 2005
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Smith, Karen M, Zinselmeyer, BH, Zinselmeyer, Bernd H, Smith, KM, Rush, C.M., Rush, Catherine M., Michael Cahalan, Ho, H., Smith, K.M., Ian Parker, Wokosin, D, Rush, Catherine M, Cahalan, M., Cahalan, Michael, Miller, M., Dempster, J., Millington, OR, Gurney, Alison M.; id_orcid, Parker, I., Ho, Hsiang, Calahan, M., Mark Miller, Millington, Owain R., Parker, I, Rush, CM, Garside, P, Alison M. Gurney, Millington, Owain R, Bernd H. Zinselmeyer, Gurney, A.M., Dempster, J, Wokosin, D.L., Paul Garside, Owain R. Millington, Millington, O.R., Catherine M. Rush, Smith, Karen M., Wokosin, D., Hsiang Ho, Dempster, John, Karen M. Smith, John Dempster, Parker, Ian, Gurney, Alison M, Brewer, James M, Gurney, Alison M., Ho, H, Cahalan, M, Millington, A.R., Wokosin, David, Zinselmeyer, B.H., Zinselmeyer, B. H., Brewer, James M., Brewer, J.M., Miller, M, Gurney, AM, David Wokosin, Garside, P., Zinselmeyer, Bernd H., Miller, Mark, James M. Brewer, Garside, Paul, Brewer, JM   +62 more
core   +4 more sources

Mucosal Chemokines [PDF]

Journal of Interferon & Cytokine Research, 2017
Several chemokines have important functions in mucosal immunity. While there are many chemokines, 4 of them (CCL25, CCL28, CXCL14, and CXCL17) are especially important in mucosal immunity because they are homeostatically expressed in mucosal tissues. Of these, only CCL25 and CCL28 have been widely recognized as mucosal chemokines.
Hernández-Ruiz, Marcela, Zlotnik, Albert   +1 more
openaire   +4 more sources

Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone

Vaccines, 2020
Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since
Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary Ostroff, Gina M. Fake, John H. Walker, Ann Kier, John A. Howard   +7 more
doaj   +1 more source

Ileal Mucosal and Fecal Pancreatitis Associated Protein Levels Reflect Severity of Salmonella Inflection in Rats [PDF]

, 2009
Background Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein.
Bovee-Oudenhoven, I.M.J., Ampting, M.T.J., van, Schonewille, A., Kramer, E., Keijer, J., Meer, R., van der, Rodenburg, G.C.H., Vink, C.   +7 more
core   +1 more source

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Stem Cells International, 2022
Cancer-derived small extracellular vesicles (sEVs) are emerging as crucial mediators of intercellular communication between cancer cells and M2-tumor-associated macrophages (M2-TAMs) via transferring lncRNAs.
Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu   +4 more
doaj   +1 more source

S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Nature Communications, 2022
HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al.
Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Céline Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombès, Johannes Roth, Maria Laura Gennaro, Frédéric Bouillaud, Sarra Cristofari, Morgane Bomsel   +14 more
doaj   +1 more source

Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague

mBio, 2021
Mice immunized with a combination of an adenovirus vector (Ad5-YFV) and live-attenuated (LMA)-based vaccines were evaluated for protective efficacy against pneumonic plague. While the Ad5-YFV vaccine harbors a fusion cassette of three genes encoding YscF,
Paul B. Kilgore, Jian Sha, Emily K. Hendrix, Vladimir L. Motin, Ashok K. Chopra   +4 more
doaj   +1 more source

Mucins in the mucosal barrier to infection [PDF]

, 2008
The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment.
Korolik, V., Linden, SK, Karlsson, N.G., Linden, S. K., McGuckin, M. A., Sutton, P, Karlsson, NG, McGuckin, MA, Korolik, V, Sutton, P.   +9 more
core   +1 more source

Editorial : Overcoming challenges in mucosal immunity : 2022 [PDF]

, 2023
The mucous-producing membranes house the highest concentration of lymphoid tissue in the vertebrate body due to their extensive interaction with the external environment.
Laceta, Javier, Leceta Martínez, Javier, Galindo-Villegas, Jorge   +2 more
core   +1 more source