Results 1 to 10 of about 608,623 (303)

Clinicopathological profile and outcomes of anorectal melanoma from a tertiary care center in India

open access: yesFuture Science OA, 2022
Background: Anorectal melanoma (AM) is a rare subtype of melanoma. Aim: To study the clinic–pathologic features and outcomes in patients with AM. Materials & methods: Clinical, pathologic findings and outcomes of patients with AM were recorded.
Vikas Garg   +8 more
doaj   +1 more source

An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma

open access: yesInternational Journal of Genomics, 2023
Head and neck squamous cell carcinoma (HNSCC) has become a prevalent malignancy, and its incidence and mortality rate are increasing worldwide. Accumulating evidence has indicated that lipid metabolism-related genes (LMRGs) are involved in the occurrence
Ling Qian   +5 more
doaj   +1 more source

Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making

open access: yesVaccines, 2023
Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes.
Kay Choong See
doaj   +1 more source

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

open access: yesCell Reports Medicine, 2021
Summary: The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally administered chimpanzee adenovirus-
Ahmed O. Hassan   +15 more
doaj   +1 more source

Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology

open access: yesFrontiers in Immunology, 2022
Herpes simplex viruses (HSV) types 1 and 2 are ubiquitous infections in humans. They cause orofacial and genital herpes with occasional severe complications. HSV2 also predisposes individuals to infection with HIV.
Jacinta B. Smith   +7 more
doaj   +1 more source

Preventive HIV Vaccines-Leveraging on Lessons from the Past to Pave the Way Forward

open access: yesVaccines, 2021
Almost four decades on, since the 1980’s, with hundreds of HIV vaccine candidates tested in both non-human primates and humans, and several HIV vaccines trials later, an efficacious HIV vaccine continues to evade us.
Parveen Sobia, Derseree Archary
doaj   +1 more source

Nano-Encapsulated Antioxidant: Retinoic Acid as a Natural Mucosal Adjuvant for Intranasal Immunization against Chronic Experimental Toxoplasmosis

open access: yesTropical Medicine and Infectious Disease, 2023
The tight relationship between immunity and retinoid levels provides evidence on the critical role of retinoic acid (RA) in regulating immune activity, especially the mucosal one.
Doaa E. Said   +5 more
doaj   +1 more source

Intranasal Single-Replication Influenza Vector Induces Cross-Reactive Serum and Mucosal Antibodies against SARS-CoV-2 Variants

open access: yesVaccines, 2023
Current SARS-CoV-2 vaccines provide protection for COVID-19-associated hospitalization and death, but remain inefficient at inhibiting initial infection and transmission. Despite updated booster formulations, breakthrough infections and reinfections from
Michael J. Moser   +7 more
doaj   +1 more source

Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro

open access: yesFrontiers in Immunology, 2022
Altering T cell trafficking to mucosal regions can enhance immune responses towards pathogenic infections and cancers at these sites, leading to better outcomes.
Kavita R. Manhas   +6 more
doaj   +1 more source

Morphology of Maxillary Labial Frenum in Chepang Community of Chitwan

open access: yesJournal of Nepal Health Research Council, 2021
Background: Labial frenum is a fold of mucous membrane whose function is to attach lips and cheek to the alveolar mucosa, gingiva and underlying periosteum. The maxillary labial frenum has lot of variation in shape, size location. This study was aimed to
Rajib Chaulagain   +2 more
doaj   +1 more source

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