Results 21 to 30 of about 305,145 (241)

Advances in the Application of Nanomaterials to the Treatment of Melanoma

Pharmaceutics, 2022
Melanoma can be divided into cutaneous melanoma, uveal melanoma, mucosal melanoma, etc. It is a very aggressive tumor that is prone to metastasis. Patients with metastatic melanoma have a poor prognosis and shorter survival.
Zeqi Wang, Yu Yu, Chuqiao Wang, Jin Li, Yan Pang   +4 more
doaj   +1 more source

TP63 is implicated in apoptotic dysregulation in melanoma [PDF]

, 2010
PhDCutaneous melanoma is an aggressive malignancy accounting for 4% of skin cancers but 80% of all skin-cancer related deaths. Its incidence is rapidly rising and advanced disease is notoriously treatment-resistant.
Matin, Rubeta N H
core   +4 more sources

Candidate therapeutic agents in a newly established triple wild‐type mucosal melanoma cell line

Cancer Communications, 2022
Background Mucosal melanoma has characteristically distinct genetic features and typically poor prognosis. The lack of representative mucosal melanoma models, especially cell lines, has hindered translational research on this melanoma subtype.
Chaoji Shi, Ziyue Gu, Shengming Xu, Houyu Ju, Yunteng Wu, Yong Han, Jiayi Li, Chuwen Li, Jing Wu, Lizhen Wang, Jiang Li, Guoyu Zhou, Weimin Ye, Guoxin Ren, Zhiyuan Zhang, Rong Zhou   +15 more
doaj   +1 more source

Primary malignant mucosal melanoma of the larynx: A case report and literature review

Journal of Pathology of Nepal, 2015
Malignant mucosal melanoma is very rare entity. It comprises about 1% of all malignant melanoma and exhibit more aggressive behaviour than that of skin melanomas.
S Shrestha Khadka, MC Lee, AB Karki
doaj   +1 more source

Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

Journal of Translational Medicine, 2019
Background Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8 months.
Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo, Yan Kong   +6 more
doaj   +1 more source

Talimogene Laherparepvec in Advanced Mucosal Melanoma of the Urethra Upon Primary Resistance on Immune Checkpoint Inhibition: A Case Report

Frontiers in Oncology, 2020
Background: Mucosal melanomas including melanomas of the urogenital tract represent a rare type of melanoma characterized by low mutational burden and poor prognosis.
Anne Fröhlich, Friederike Hoffmann, Dennis Niebel, Eva Egger, Guido M. Kukuk, Marieta Toma, Judith Sirokay, Thomas Bieber, Jennifer Landsberg   +8 more
doaj   +1 more source

miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

Journal of Experimental & Clinical Cancer Research, 2019
Background Mucosal melanoma with poor prognosis is a common histopathologic subtype of melanoma among Chinese and other Asian peoples. Regulated microRNAs (miRNAs) have been reported as oncogenes or tumour suppressors in melanoma.
Huan Tang, Meng Ma, Jie Dai, Chuanliang Cui, Lu Si, Xinan Sheng, Zhihong Chi, Longwen Xu, Sifan Yu, Tianxiao Xu, Junya Yan, Huan Yu, Lu Yang, Yan Kong, Jun Guo   +14 more
doaj   +1 more source

Sequential Combination Chemotherapy of Dacarbazine (DTIC) with Carboplatin and Paclitaxel for Patients with Metastatic Mucosal Melanoma of Nasal Cavity and Paranasal Sinuses

Clinical Medicine Insights: Case Reports, 2017
By the recent introduction of molecular targeting drugs against BRAF mutation and immune checkpoint inhibitors, the prognosis of patients with melanoma in advanced stage is now improving, but still in the minority.
W. Omata, A. Tsutsumida, K. Namikawa, A. Takahashi, K. Oashi, N. Yamazaki   +5 more
doaj   +1 more source

Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas

Cells, 2020
Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in ...
Piotr Donizy, Cheng-Lin Wu, Jason Mull, Masakazu Fujimoto, Agata Chłopik, Yan Peng, Sara C. Shalin, M. Angelica Selim, Susana Puig, Maria-Teresa Fernandez-Figueras, Christopher R. Shea, Wojciech Biernat, Janusz Ryś, Andrzej Marszalek, Mai P. Hoang   +14 more
doaj   +1 more source

Advances in Understanding Spontaneously Occurring Melanoma in Animals

Veterinary Sciences, 2023
Melanoma is a tumour that arises from the uncontrolled proliferation of melanocytes (pigment-producing cells) found in the skin (cutaneous melanoma and digital melanoma), mucosal surfaces (oral melanoma), and the eye (ocular melanoma) [...]
Kelly L. Blacklock, Louise van der Weyden   +1 more
doaj   +1 more source