Results 21 to 30 of about 489 (129)

The Role of MukE in Assembling a Functional MukBEF Complex [PDF]

Journal of Molecular Biology, 2011
The MukB-MukE-MukF protein complex is essential for chromosome condensation and segregation in Escherichia coli. The central component of this complex, the MukB protein, is related functionally and structurally to the ubiquitous SMC (structural maintenance of chromosomes) proteins.
Melanie, Gloyd, Rodolfo, Ghirlando, Alba, Guarné   +2 more
openaire   +3 more sources

Distinct Activities of Bacterial Condensins for Chromosome Management in Pseudomonas aeruginosa

Cell Reports, 2020
Summary: Three types of structurally related structural maintenance of chromosomes (SMC) complexes, referred to as condensins, have been identified in bacteria.
Virginia S. Lioy, Ivan Junier, Valentine Lagage, Isabelle Vallet, Frédéric Boccard   +4 more
doaj   +2 more sources

Transient growth arrest in Escherichia coli induced by chromosome condensation. [PDF]

PLoS ONE, 2013
MukB is a bacterial SMC (structural maintenance of chromosome) protein that regulates the global folding of the Escherichia coli chromosome by bringing distant DNA segments together.
Andrea L Edwards, Dipen P Sangurdekar, Kyeong S Jeong, Arkady B Khodursky, Valentin V Rybenkov   +4 more
doaj   +3 more sources

Bacterial chromosome organization by condensins : functional analysis of MukBEF in E.coli

, 2023
La condensation des chromosomes et leur ségrégation sont deux processus essentiels à la transmission du matériel génétique chez tous les êtres vivants. En effet, les chromosomes sont constitués d'une molécule d'ADN et de plusieurs familles de protéines qui assurent plusieurs fonctions liées à l'ADN.
Seba, Mohammed
openaire   +2 more sources

MukBEF, a Chromosomal Organizer [PDF]

Microbial Physiology, 2014
Global folding of bacterial chromosome requires the activity of condensins. These highly conserved proteins are involved in various aspects of higher-order chromatin dynamics in a diverse range of organisms. Two distinct superfamilies of condensins have been identified in bacteria.
Valentin V, Rybenkov, Viridiana, Herrera, Zoya M, Petrushenko, Hang, Zhao   +3 more
openaire   +2 more sources

Characterization of the conserved features of the NSE6 subunit of the Physcomitrium patens SMC5/6 complex

The Plant Journal, Volume 115, Issue 4, Page 1084-1099, August 2023., 2023
Significance Statement The understanding of the role of the structural maintenance of chromosomes (SMC) 5/6 complexes in plants, particularly of the NSE5 and NSE6 subunits, is poor. We identified a previously unrecognized NSE6 motif mediating interaction with NSE5 and mapped the Physcomitrium patens PpNSE6‐binding site at the PpSMC5 arm. These findings
Edit Lelkes, Jitka Jemelková, Marcela Holá, Barbora Štefanovie, Peter Kolesár, Radka Vágnerová, Eva Dvořák Tomaštíková, Ales Pecinka, Karel J. Angelis, Jan J. Paleček   +9 more
wiley   +1 more source

Targeting Essential Hypothetical Proteins of Pseudomonas aeruginosa PAO1 for Mining of Novel Therapeutics: An In Silico Approach

BioMed Research International, Volume 2023, Issue 1, 2023., 2023
As an omnipresent opportunistic bacterium, Pseudomonas aeruginosa PAO1 is responsible for acute and chronic infection in immunocompromised individuals. Currently, this bacterium is on WHO’s red list where new antibiotics are urgently required for the treatment.
Atikur Rahman, Md. Takim Sarker, Md Ashiqul Islam, Mohammad Uzzal Hossain, Mahmudul Hasan, Tasmina Ferdous Susmi, Luis Morales-Quintana   +6 more
wiley   +1 more source

Nucleoid‐associated Rok differentially affects chromosomal transformation on Bacillus subtilis recombination‐deficient cells

Environmental Microbiology, Volume 23, Issue 6, Page 3318-3331, June 2021., 2021
Summary Rok, a Bacillus subtilis nucleoid‐associated protein (NAP), negatively regulates competence development and silences xenogeneic genes. We show that rok inactivation increases rpoB482 natural intraspecies chromosomal transformation (CT) and plasmid transformation to a different extent.
Ester Serrano, Rubén Torres, Juan C. Alonso   +2 more
wiley   +1 more source

Cancer‐associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges

Journal of Cellular Physiology, Volume 236, Issue 5, Page 3579-3598, May 2021., 2021
The condensin II complex mutations R551P, R551S, and S556F cause genomic instability by causing DNA damage, anaphase defects, micronuclei, and chromosomal instability. DNA damage and anaphase defects are caused primarily by ataxia telangiectasia and Rad3‐related‐dependent telomere dysfunction.
Emily Weyburne, Giovanni Bosco
wiley   +1 more source

DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis

BioEssays, Volume 43, Issue 4, April 2021., 2021
DNA topoisomerases are fundamental to the life of all cells due to their numerous roles in DNA metabolic processes; this includes transcription, replication, chromosome segregation, DNA repair, neurodevelopment, tumour suppression, mitochondrial DNA maintenance, and RNA processing, with new roles still being actively elucidated 50 years after their ...
Shannon J. McKie, Keir C. Neuman, Anthony Maxwell   +2 more
wiley   +1 more source