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BioEssays, Volume 43, Issue 4, April 2021., 2021 DNA topoisomerases are fundamental to the life of all cells due to their numerous roles in DNA metabolic processes; this includes transcription, replication, chromosome segregation, DNA repair, neurodevelopment, tumour suppression, mitochondrial DNA maintenance, and RNA processing, with new roles still being actively elucidated 50 years after their ...
Shannon J. McKie +2 more
wiley +1 more source
A mechanistic understanding of bacterial chromosome organisation [PDF]
, 2023 Chromosomes serve as repositories of genetic information, crucial to the functionality of all living organisms. Bacteria, in their simplicity, offer an ideal model to investigate the intricacies of chromosomal dynamics.
Sadhir, Ismath
core +1 more source
The MaoP/maoS Site-Specific System Organizes the Ori Region of the E. coli Chromosome into a Macrodomain. [PDF]
PLoS Genetics, 2016 The Ori region of bacterial genomes is segregated early in the replication cycle of bacterial chromosomes. Consequently, Ori region positioning plays a pivotal role in chromosome dynamics. The Ori region of the E.
Michèle Valens +2 more
doaj +1 more source
Chromosome Condensation in the Absence of the Non-SMC Subunits of MukBEF [PDF]
Journal of Bacteriology, 2006 ABSTRACTMukBEF is a bacterial SMC (structural maintenance of chromosome) complex required for chromosome partitioning inEscherichia coli. We report that overproduction of MukBEF results in marked chromosome condensation. This condensation is rapid and precedes the effects of overproduction on macromolecular synthesis.
Qinhong, Wang +3 more
openaire +2 more sources
Distinct Activities of Bacterial Condensins for Chromosome Management in Pseudomonas aeruginosa
Cell Reports, 2020 Summary: Three types of structurally related structural maintenance of chromosomes (SMC) complexes, referred to as condensins, have been identified in bacteria.
Virginia S. Lioy +4 more
doaj +1 more source
Using Fluorescence Recovery After Photobleaching (FRAP) to study dynamics of the Structural Maintenance of Chromosome (SMC) complex in vivo [PDF]
, 2016 The SMC complex, MukBEF, is important for chromosome organization and segregation in Escherichia coli. Fluorescently tagged MukBEF forms distinct spots (or 'foci') in the cell, where it is thought to carry out most of its chromosome associated activities.
A Badrinarayanan +21 more
core +2 more sources
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Alipour +57 more
core +6 more sources
3D Organization of Eukaryotic and Prokaryotic Genomes [PDF]
, 2020 There is a complex mutual interplay between three-dimensional (3D) genome organization and cellular activities in bacteria and eukaryotes. The aim of this thesis is to investigate such structure-function relationships. A main part of this thesis deals
Hofmann, Andreas
core +1 more source
Mechanics of DNA bridging by bacterial condensin MukBEF in vitro and in singulo [PDF]
The EMBO Journal, 2010 Structural maintenance of chromosome (SMC) proteins comprise the core of several specialized complexes that stabilize the global architecture of the chromosomes by dynamically linking distant DNA fragments. This reaction however remains poorly understood giving rise to numerous proposed mechanisms of the proteins.
Zoya M, Petrushenko +3 more
openaire +2 more sources
Bacterial Chromosome Organization and Segregation [PDF]
, 2018 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is ...
Badrinarayanan, Anjana +2 more
core +1 more source