Results 101 to 110 of about 3,358,336 (306)

Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Gene Fragment Libraries

, 2018
The unique property of specific high affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications.
Rockberg, Johan,, Anna-Luisa Volk, Johan Rockberg, Volk, Anna-Luisa,, Hu, Francis Jingxin,, Francis Jingxin Hu   +5 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Design of a Multi-Epitope Vaccine against Histoplasma capsulatum through Immunoinformatics Approaches

Journal of Fungi
Histoplasmosis is a widespread systemic disease caused by Histoplasma capsulatum, prevalent in the Americas. Despite its significant morbidity and mortality rates, no vaccines are currently available.
Pedro Henrique Marques, Sandeep Tiwari, Andrei Giacchetto Felice, Arun Kumar Jaiswal, Flávia Figueira Aburjaile, Vasco Azevedo, Mario León Silva-Vergara, Kennio Ferreira-Paim, Siomar de Castro Soares, Fernanda Machado Fonseca   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bioinformatics analysis for the purpose of designing a novel multi-epitope DNA vaccine against Leishmania major

, 2022
Leishmaniasis is one of the main infectious diseases worldwide. In the midst of all the different forms of the disease, Cutaneous Leishmania (CL) has the highest incidence in the world.
Rashidi, S., Hatam, S., Mamaghani, Amirreza Javadi, Hatam, Gholamreza, Bemani, Peyman, Rashidi, Sama, Kazemi, B., Faraji, Seyed Nooreddin, Hatam, Saeid, Mamaghani, A. J., Tabaei, S. J. S., Bemani, P., Tabaei, Seyyed Javad Seyyed, Kazemi, Bahram, Faraji, S. N., Hatam, G.   +15 more
core   +1 more source

Comparison of BP26, Omp25 and Omp31 and a Multiepitope-Based Fusion Protein in the Serological Detection of Canine Brucellosis

Infection and Drug Resistance, 2022
Meixue Yao,1,* Mengda Liu,2,* Xia Chen,3 Jianjun Li,4 Yan Li,5 Yu Run Wei,2 Yong Liu,3 Kang Long Yang,3 Xiaoxiao Duan,5 Weixing Shao,2 Xiangxiang Sun,2 Xiaoxu Fan,2 Shufang Sun,2 Lili Tian,2 Dehui Yin,1 Mingjun Sun2 1Key Laboratory of Human ...
Yao M, Liu M, Chen X, Li J, Li Y, Wei YR, Liu Y, Yang KL, Duan X, Shao W, Sun X, Fan X, Sun S, Tian L, Yin D, Sun M   +15 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

Systemic flowchart of the multi-epitope subunit vaccines build against HCV.

, 2022
Systemic flowchart of the multi-epitope subunit vaccines build against HCV.
Sohrab Najafipour (13531684), Ebrahim Barzegari (3301023), Saade Abdalkareem Jasim (12178300), Esmaeil Behmard (4845154), Amin Kouhpayeh (13531693), Hussein T. Abdulabbas (13531681), Abdolmajid Ghasemian (13531687), Akbar Farjadfar (13531690), Parviz Abdolmaleki (9078721)   +8 more
core   +1 more source