Results 121 to 130 of about 3,358,336 (306)

Proteolytic Fragmentation for Epitope Mapping

, 2009
The use of antigen fragments generated by specific proteolytic cleavage is a relatively simple "library" approach for epitope mapping in which possible overlapping fragments are screened with the antibody on Western blots.
HAMM H. E., PORCHIA F, MAZZONI, MARIA ROSA   +2 more
core   +1 more source

A Universal Multi-Epitope Vaccine Design Against Porcine Reproductive and Respiratory Syndrome Virus via Bioinformatics and Immunoinformatics Approaches

Veterinary Sciences
Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive disorders in sows and severe pneumonia in piglets, alongside immunosuppressive effects on the host.
Xinnuo Lei, Zhi Wu, Qi Feng, Wenfeng Jia, Jun Xie, Qingkang Zhou, Jinzhao Ban, Shanyuan Zhu   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The predicted three-dimensional structure of multi-epitope vaccine.

The predicted three-dimensional structure of multi-epitope vaccine.
Mohammad Yousefian Langeroudi (17720814), Rasoul Daneshi (17720811), Mahsa Rabienia (17720805), Abbas Abdollahi (5663017), Esmaeil Behmard (4845154), Nahid Mortazavidehkordi (17720808), Zahra Roudbari (16413534), Akbar Farjadfar (13531690)   +7 more
core   +1 more source

Construction and evaluation of a Salmonella minicell-based dendritic cell-targeted multi-epitope vaccine against Helicobacter pylori

Frontiers in Immunology
BackgroundHelicobacter pylori (H. pylori) infection is a global health concern linked to various gastrointestinal diseases, highlighting the urgent need for effective vaccines.MethodsIn this study, we developed two multi-epitope vaccine candidates based ...
Jiaxue Yang, Kehan Chen, Yalan Zhu, Tiancheng Xie, Chubin Fang, Chuan Wang, Chuan Wang, Tian Tang, Tian Tang   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Validation factors for TLR11 and final multi-epitope vaccine models.

Validation factors for TLR11 and final multi-epitope vaccine models.
Mohammad Yousefian Langeroudi (17720814), Rasoul Daneshi (17720811), Mahsa Rabienia (17720805), Abbas Abdollahi (5663017), Esmaeil Behmard (4845154), Nahid Mortazavidehkordi (17720808), Zahra Roudbari (16413534), Akbar Farjadfar (13531690)   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice

, 2014
We evaluated the immunogenicity and efficacy of a candidate vaccine comprising the major outer membrane protein (MOMP) multi-epitope of Chlamydia trachomatis.
Xiaoyun Lin, Wang, Bingbing, Bingbing Wang, Lifang Zhang, Xue, Xiangyang, Zhao, Kong-Nan, Bailong Hou, Wenci Gong, Chen, Shao, Zhang, Lifang, Kong-Nan Zhao, Lin, Xiaoyun, Hou, Bailong, Zhu, Shanli, Xiangyang Xue, Tu, Jianxin, Haiyan Dong, Shao Chen, Shanli Zhu, Jianxin Tu, Gong, Wenci, Dong, Haiyan   +21 more
core   +1 more source