Results 131 to 140 of about 3,358,336 (306)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Development of multi-epitope Cathepsin L driven short peptide vaccine against Fasciola gigantica

Frontiers in Veterinary Science
Fasciolosis is an important zoonotic disease caused by Fasciola species (Fasciola spp.). Fasciola spp. infection has the potential to affect the livestock economy.
Supanan Chansap, Werachon Cheukamud, Thitikul Suthisintong, Pornanan Kueakhai, Narin Changklungmoa   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Computational Development of Multi-Epitope Reovirus Vaccine with Potent Predicted Binding to TLR2 and TLR4

Pharmaceuticals
Background: Mammalian orthoreovirus is a ubiquitous double-stranded RNA virus that causes mild respiratory and enteric infections, primarily in infants and young children.
Abdullah Al Noman, Abdulrahman Mohammed Alhudhaibi, Pranab Dev Sharma, Sadia Zafur Jannati, Tahamina Akhter, Samira Siddika, Kaniz Fatama Khan, Tarek H. Taha, Sulaiman A. Alsalamah, Emad M. Abdallah   +9 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer

Frontiers in Medicine
IntroductionProstate cancer remains a major global health challenge, necessitating precision immunotherapeutic strategies tailored to tumor-associated antigens.
Stefanus Vicky Bernhard Elisa Runtunuwu, Trina Ekawati Tallei, Trina Ekawati Tallei, Trina Ekawati Tallei, Hyo Jeong Kim, Moon Nyeo Park, Moon Nyeo Park, Ismail Celik, Burak Kirilmaz, Grace Lendawati Amelia Turalaki, Fatimawali Fatimawali, Lydia Estelina Naomi Tendean, Martha Marie Kaseke, Dionisius Rafael Makawaehe, Elne Vieke Rambi, Bonglee Kim, Bonglee Kim   +16 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Epitope-driven common subunit vaccine design against H. pylori strains

, 2018
The developing potent vaccine is a pre-emptive strategy to tackle drug abuses and maladies of multidrug-resistant Helicobacter pylori strains. Ongoing vaccine studies are being conducted, however, development is in its infancy as ineffective vaccine ...
Ravina Madhulitha Nalamolu (6115376), Chiranjeevi Pasala (6115373), Aparna R. Bitla (6115379), Sudheer Kumar Katari (5877476), Umamaheswari Amineni (6161747), Chandra Sekhar Reddy Chilamakuri (7270157)   +5 more
core   +1 more source

In silico analysis for the development of multi-epitope vaccines against Mycobacterium tuberculosis

Frontiers in Immunology
As Bacille Calmette-Guérin (BCG) vaccine’s effectiveness is limited to only children, the development of new tuberculosis (TB) vaccines is being studied using several platforms, and a novel TB vaccine that overcomes this limitation is required.
Jin-Seung Yun, Jin-Seung Yun, A Reum Kim, Soo Min Kim, Eunkyung Shin, Sang-Jun Ha, Dokeun Kim, Hye-Sook Jeong   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source