Results 11 to 20 of about 79,223 (384)

A candidate multi-epitope vaccine against SARS-CoV-2 [PDF]

Scientific Reports, 2020
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively.
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, F. Castiglione, D. Mueller, A. Srivastava   +6 more
semanticscholar   +7 more sources

Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics

Frontiers in Immunology
Helicobacter pylori (H. pylori) is an infectious bacterium that colonizes the stomach of approximately half of the global population. It has been classified as a Group I carcinogen by the World Health Organization due to its strong association with an ...
Man Cui, Man Cui, Xiaohui Ji, Xiaohui Ji, Fengtao Guan, Fengtao Guan, Guimin Su, Guimin Su, Lin Du, Lin Du   +9 more
doaj   +4 more sources

A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

Frontiers in Microbiology
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu   +9 more
doaj   +2 more sources

Designing a multi-epitope peptide based vaccine against SARS-CoV-2 [PDF]

Scientific Reports, 2020
Abstract COVID-19 pandemic has resulted in 16,114,449 cases with 646,641 deaths from the 217 countries, or territories as on July 27th 2020. Due to multifaceted issues and challenges in the implementation of the safety and preventive measures, inconsistent coordination between societies-governments and most ...
Abhishek Singh, Mukesh Thakur, Lalit Kumar Sharma, Kailash Chandra   +3 more
openalex   +4 more sources

The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model

Frontiers in Immunology, 2022
Emerging data have suggested that single short peptides have limited success as a cancer vaccine; however, extending the short peptides into longer multi-epitope peptides overcame the immune tolerance and induced an immune response.
Thi-Anh-Thuy Tran, Thi-Anh-Thuy Tran, Young-Hee Kim, Ga-Eun Kim, Shin Jung, Shin Jung, In-Young Kim, In-Young Kim, Kyung-Sub Moon, Kyung-Sub Moon, Young-Jin Kim, Young-Jin Kim, Tae-Kyu Lee, Tae-Kyu Lee, Hyosuk Yun, Je-Jung Lee, Je-Jung Lee, Hyun-Ju Lee, Chul Won Lee, Tae-Young Jung, Tae-Young Jung, Tae-Young Jung   +21 more
doaj   +1 more source

Multi-epitope vaccine candidate design for dengue virus

Bioinformation, 2023
Dengue Fever (DF) is a vector-borne neglected viral disease with a high burden in the sub-tropics of Asia and Africa. Aedes aegypti is responsible for 90% of cases in the global burden of disease. The primary goal of the treatment is to eliminate the virus from the bloodstream of affected individuals.
Dharani, A, Ezhilarasi, DR, Priyadarsini, G, Abhinand, PA   +3 more
openaire   +2 more sources

A Computational Reverse Vaccinology Approach for the Design and Development of Multi-Epitopic Vaccine Against Avian Pathogen Mycoplasma gallisepticum

Frontiers in Veterinary Science, 2021
Avian mycoplasma is a bacterial disease causing chronic respiratory disease (CRD) in poultry industries with high economic losses. The eradication of this disease still remains as a challenge.
Susithra Priyadarshni Mugunthan, Harish Mani Chandra   +1 more
doaj   +1 more source

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]

, 2012
Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias, Brynza, Julia, Buchholz, Christian J., Kneissl, Sabrina, Rasbach, Anke, Schneider-Schaulies, Jürgen   +5 more
core   +16 more sources

The Construction of A Multi-epitope Vaccine Against Klebsiella pneumoniae Using in silico Approach

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Klebsiella pneumoniae is one of the bacteria that causes pneumonia infection. Even though the number of pneumonia cases is relatively high and has become a global problem, there is still no vaccine available to prevent this disease.
Dhammiko Wonggo, Mariana Wahjudi
doaj   +1 more source

Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics

Heliyon, 2020
Rotavirus is the most common cause of acute gastroenteritis in infants and children worldwide. The functional correlation of B- and T-cells to long-lasting immunity against rotavirus infection in the literature is limited.
Yengkhom Damayanti Devi, Arpita Devi, Hemanga Gogoi, Bondita Dehingia, Robin Doley, Alak Kumar Buragohain, Ch. Shyamsunder Singh, Partha Pratim Borah, C.Durga Rao, Pratima Ray, George M. Varghese, Sachin Kumar, Nima D. Namsa   +12 more
doaj   +1 more source