Results 11 to 20 of about 36,032 (319)

Immunoinformatics-driven design of a multi-epitope vaccine against nipah virus: A promising approach for global health protection [PDF]

Journal of Genetic Engineering and Biotechnology
This study focuses on developing a multi-epitope vaccine against the highly pathogenic Nipah virus using immunoinformatics. It aims to design a vaccine targeting the viral nucleoprotein to elicit robust immune responses.
Muhammad Aqib Shabbir, Ammara Amin, Ammarah Hasnain, Ayesha Shakeel, Ambreen Gul   +4 more
doaj   +2 more sources

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis [PDF]

Frontiers in Immunology
BackgroundUveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design
He Cao, Zhi Cao, Yue Han, Jing Shan
doaj   +2 more sources

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis [PDF]

Parasites & Vectors
Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for ...
Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu   +7 more
doaj   +2 more sources

Identification of Class I HLA T Cell Control Epitopes for West Nile Virus [PDF]

, 2013
The recent West Nile virus (WNV) outbreak in the United States underscores the importance of understanding human immune responses to this pathogen.
A Harari, A Sette, A Wahl, AC Tan, B Custer, B Shrestha, BC Braun, BEE Martina, BF Haynes, Charles R. Rinaldo, CP McMurtrey, Curtis P. McMurtrey, D Weiskopf, Diana M. Campbell, EB Bell, F Mostashari, Fredda B. Schafer, HD Hickman, HL Robinson, HL Smith, HM Jackson, J Roelse, JW Yewdell, K Eneslatt, K Prilliman, Kenneth W. Jackson, KR Prilliman, L Rodriguez Mde, M De Filette, MG Duvall, MP Busch, MR Leach, MS Diamond, MS Diamond, MS Diamond, MS Leffell, MV Larsen, N Caccamo, P Piazza, PA Wearsch, Paolo A. Piazza, PM Kloetzel, R Buchli, Rico Buchli, RS Akondy, S Kim, Saghar Kaabinejadian, Stephen R. Vernon, Steven J. Cate, T Oliphant, Tian Wang, U Seifert, WG Glass, Wilfried Bardet, William H. Hildebrand, Y Lin, Y Wang   +56 more
core   +27 more sources

Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention [PDF]

Frontiers in Immunology, 2021
BackgroundOverexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with poor prognosis could be effective vaccine antigens.
Ekram Gad, Andrew L. Coveler, Denise L. Cecil, Ronald A. Lubet, Jennifer Childs, Mary L. Disis, Lauren R. Corulli, Marlese Koehnlein   +7 more
openaire   +4 more sources

The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model

Frontiers in Immunology, 2022
Emerging data have suggested that single short peptides have limited success as a cancer vaccine; however, extending the short peptides into longer multi-epitope peptides overcame the immune tolerance and induced an immune response.
Thi-Anh-Thuy Tran, Thi-Anh-Thuy Tran, Young-Hee Kim, Ga-Eun Kim, Shin Jung, Shin Jung, In-Young Kim, In-Young Kim, Kyung-Sub Moon, Kyung-Sub Moon, Young-Jin Kim, Young-Jin Kim, Tae-Kyu Lee, Tae-Kyu Lee, Hyosuk Yun, Je-Jung Lee, Je-Jung Lee, Hyun-Ju Lee, Chul Won Lee, Tae-Young Jung, Tae-Young Jung, Tae-Young Jung   +21 more
doaj   +1 more source

Computational Design of a Multi-Epitope Vaccine Against Porphyromonas gingivalis [PDF]

Frontiers in Immunology, 2022
Porphyromonas gingivalisis a Gram-negative pathogenic bacterium associated with chronic periodontitis. The development of a chimeric peptide-based vaccine targeting this pathogen could be highly beneficial in preventing oral bone loss as well as other severe gum diseases.
Bilal Shaker, Sajjad Ahmad, Junhao Shen, Hyung Wook Kim, Dokyun Na   +4 more
openaire   +3 more sources

A Computational Reverse Vaccinology Approach for the Design and Development of Multi-Epitopic Vaccine Against Avian Pathogen Mycoplasma gallisepticum

Frontiers in Veterinary Science, 2021
Avian mycoplasma is a bacterial disease causing chronic respiratory disease (CRD) in poultry industries with high economic losses. The eradication of this disease still remains as a challenge.
Susithra Priyadarshni Mugunthan, Harish Mani Chandra   +1 more
doaj   +1 more source

Exploring YidR Gene from Klebsiella pneumoniae To Design a Multi-epitope Vaccine Using Immunoinformatics Approach

Journal of Experimental Life Science, 2022
Klebsiella pneumoniae is the main leading cause of hospital-acquired infection, leading to severe infections such as pneumonia and urinary tract infection.
Maulana Wildan Seputra, Hani Susiati, Tri Yudani Mardining Raras   +2 more
doaj   +1 more source

A Candidate multi-epitope vaccine against SARS-CoV-2 [PDF]

Scientific Reports, 2020
Abstract In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively. Currently, the entire world is facing a pandemic of another coronavirus, SARS-CoV-2, with a high fatality rate.
Kar Tamalika, Narsaria Utkarsh, Basak Srijita, Deb Debashrito, Castiglione Filippo, Mueller David M, Srivastava Anurag P   +6 more
openaire   +7 more sources