Results 21 to 30 of about 79,223 (384)
In silico design of recombinant multi-epitope vaccine against influenza A virus
BMC Bioinformatics, 2022 Background Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production.
Avisa Maleki +3 more
doaj +1 more source
Computational Design of a Multi-Epitope Vaccine Against Porphyromonas gingivalis [PDF]
Frontiers in Immunology, 2022 Porphyromonas gingivalisis a Gram-negative pathogenic bacterium associated with chronic periodontitis. The development of a chimeric peptide-based vaccine targeting this pathogen could be highly beneficial in preventing oral bone loss as well as other severe gum diseases.
Bilal Shaker +4 more
openaire +3 more sources
Scientific Reports, 2023 Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo +4 more
doaj +1 more source
Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention [PDF]
Frontiers in Immunology, 2021 BackgroundOverexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with poor prognosis could be effective vaccine antigens.
Lauren R. Corulli +7 more
openaire +3 more sources
PLoS ONE, 2023 Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope vaccine against MPXV ...
Samira Sanami +8 more
semanticscholar +1 more source
Immunogenicity of a multi-epitope DNA vaccine against hantavirus [PDF]
Human Vaccines & Immunotherapeutics, 2012 Hemorrhagic fever with renal syndrome (HFRS) is a severe epidemic disease caused by hantaviruses including Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV) and Puumala virus. Three of the four HFRS hantaviruses, HTNV, SEOV, and PUUV are found in China. Currently, there is no effective strategy available to reduce infection risk.
Chen, Zhao +7 more
openaire +2 more sources
Computer-Aided Multi-Epitope Vaccine Design against Enterobacter xiangfangensis
International Journal of Environmental Research and Public Health, 2022 Antibiotic resistance is a global public health threat and is associated with high mortality due to antibiotics’ inability to treat bacterial infections. Enterobacter xiangfangensis is an emerging antibiotic-resistant bacterial pathogen from the Enterobacter genus and has the ability to acquire resistance to multiple antibiotic classes.
Abdulrahman Alshammari +9 more
openaire +2 more sources
DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]
, 2016 Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B +8 more
core +8 more sources
Informatics in Medicine Unlocked, 2022 Research has shown the implication of Penicillin-Binding Protein 2A (PBP2A) as a critical factor in Methicillin-Resistant Staphylococcus aureus (MRSA) as it confers resistance to β‐lactam antibiotics on S.
Simeon Kayowa Olatunde +2 more
doaj +1 more source
Influenza Evolution and H3N2 Vaccine Effectiveness, with Application to the 2014/2015 Season [PDF]
, 2016 Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness.
Deem, Michael W., Li, Xi
core +2 more sources