Results 21 to 30 of about 36,032 (319)

The Construction of A Multi-epitope Vaccine Against Klebsiella pneumoniae Using in silico Approach

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Klebsiella pneumoniae is one of the bacteria that causes pneumonia infection. Even though the number of pneumonia cases is relatively high and has become a global problem, there is still no vaccine available to prevent this disease.
Dhammiko Wonggo, Mariana Wahjudi
doaj   +1 more source

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

International Journal of Environmental Research and Public Health, 2022
Antibiotic resistance (AR) is the result of microbes’ natural evolution to withstand the action of antibiotics used against them. AR is rising to a high level across the globe, and novel resistant strains are emerging and spreading very fast. Acinetobacter baumannii is a multidrug resistant Gram-negative bacteria, responsible for causing severe ...
Miraj ud-din, Aqel Albutti, Asad Ullah, Saba Ismail, Sajjad Ahmad, Anam Naz, Muhammad Khurram, Mahboob ul Haq, Zobia Afsheen, Youness El Bakri, Muhammad Salman, Bilal Shaker, Muhammad Tahir ul Qamar   +12 more
openaire   +2 more sources

Multi-epitope peptide vaccines for human lymphatic filariasis [PDF]

International Journal of Infectious Diseases, 2014
The rise of drug-resistant tuberculosis threatens the very fabric of traditional tuberculosis control efforts, particularly in South Africa, Eastern Europe and parts of Asia. Initial complacency was guided by laboratory observations which suggested that drug-resistant strains of Mycobacterium tuberculosis are less transmissible than drug-susceptible ...
Gandhirajan Anugraha, Maryada Venkata Rami Reddy, J. Madhumathi, Donthamsetty Nageswara Rao, Perumal Kaliraj, P.R. Prince   +5 more
openaire   +3 more sources

Immunogenicity of a multi-epitope DNA vaccine against hantavirus [PDF]

Human Vaccines & Immunotherapeutics, 2012
Hemorrhagic fever with renal syndrome (HFRS) is a severe epidemic disease caused by hantaviruses including Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV) and Puumala virus. Three of the four HFRS hantaviruses, HTNV, SEOV, and PUUV are found in China. Currently, there is no effective strategy available to reduce infection risk.
Tongtong Yu, Feng Du, Enjie Luo, Ying Sun, Si Wang, Chen Zhao, X. Frank Yang, Yujie Zhao   +7 more
openaire   +2 more sources

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Scientific Reports, 2023
Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo, Xiaohong Pan, Qiangming Sun, Yunzhang Hu, Jiandong Shi   +4 more
doaj   +1 more source

Multi-epitope vaccine candidate design for dengue virus

Bioinformation, 2023
Dengue Fever (DF) is a vector-borne neglected viral disease with a high burden in the sub-tropics of Asia and Africa. Aedes aegypti is responsible for 90% of cases in the global burden of disease. The primary goal of the treatment is to eliminate the virus from the bloodstream of affected individuals.
Dharani, A, Ezhilarasi, DR, Priyadarsini, G, Abhinand, PA   +3 more
openaire   +2 more sources

Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach

Vaccines, 2022
Currently, there are limited treatment options available for the monkeypox disease. We used a computational strategy to design a specific antigenic vaccine against pathogens. After using various immunoinformatic tools and filters, cytotoxic T-cell lymphocyte (CTL)-, helper T-cell lymphocyte (HTL)-, and interferon gamma (IFN-γ)-inducing epitopes, which ...
Sayed Aliul Hasan Abdi, Amena Ali, Shabihul Fatma Sayed, null Abutahir, Abuzer Ali, Prawez Alam   +5 more
openaire   +3 more sources

Ymir: A 3D structural affinity model for multi-epitope vaccine simulations [PDF]

iScience, 2021
Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation. The strength and breadth of antibody responses relies on selection and mutation in the germinal center and on the structural similarity between antigens.
Robert, Philippe A., Arulraj, Theinmozhi, Meyer-Hermann, Michael   +2 more
openaire   +4 more sources

Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic? [PDF]

Academia Letters, 2021
Problems associated with Wuhan spike protein-based vaccines are the emergence of new SARS-CoV-2 strains that are more or less resistant to Wuhan spike protein-based vaccine-induced immunity, and toxicity of the spike protein (S protein alone can damage vascular endothelial cells).
openaire   +3 more sources

In silico Design of a Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Multi-Epitope Antigen for Vaccine Development

Zoonoses, 2022
No licensed vaccine is available to prevent the severe tick-borne disease Crimean-Congo hemorrhagic fever (CCHF), caused by the CCHF virus (CCHFV). This study sought to show that a combination of computational methods and data from published literature ...
Megan C. Mears, Dennis A. Bente
doaj   +1 more source