Results 11 to 20 of about 136,187 (283)

scMoC: single-cell multi-omics clustering [PDF]

Bioinformatics Advances, 2021
Abstract Motivation Single-cell multi-omics assays simultaneously measure different molecular features from the same cell. A key question is how to benefit from the complementary data available and perform cross-modal clustering of cells.
Mostafa Eltager, Tamim Abdelaal, Ahmed Mahfouz, Marcel J T Reinders   +3 more
openaire   +5 more sources

Editorial: Multi-omic data integration [PDF]

Frontiers in Cell and Developmental Biology, 2015
As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter. The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions ...
Christine eNardini, Christine eNardini, Jennifer eDent, Paolo eTieri   +3 more
openaire   +5 more sources

Multi-Omics Profiling for Health

Molecular & Cellular Proteomics, 2023
The world has witnessed a steady rise in both non-infectious and infectious chronic diseases, prompting a cross-disciplinary approach to understand and treating disease. Current medical care focuses on treating people after they become patients rather than preventing illness, leading to high costs in treating chronic and late-stage diseases ...
Mohan Babu, Michael Snyder
openaire   +2 more sources

Osteosarcoma Multi-Omics Landscape and Subtypes

Cancers, 2022
Osteosarcoma (OS) is the most common primary bone malignancy that exhibits remarkable histologic diversity and genetic heterogeneity. The complex nature of osteosarcoma has confounded precise molecular categorization, prognosis, and prediction for this disease. In this study, we performed a comprehensive multiplatform analysis on 86 osteosarcoma tumors,
Shan Tang, Ryan D. Roberts, Lijun Cheng, Lang Li   +3 more
openaire   +2 more sources

KeyPathwayMinerWeb: online multi-omics network enrichment [PDF]

Nucleic Acids Research, 2016
We present KeyPathwayMinerWeb, the first online platform for de novo pathway enrichment analysis directly in the browser. Given a biological interaction network (e.g. protein-protein interactions) and a series of molecular profiles derived from one or multiple OMICS studies (gene expression, for instance), KeyPathwayMiner extracts connected sub ...
Markus List, Nicolas Alcaraz, Martin Dissing-Hansen, Henrik J. Ditzel, Jan Mollenhauer, Jan Baumbach   +5 more
openaire   +4 more sources

Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats

Journal of Translational Medicine, 2023
Background Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb motor function.
Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li, Zijian Xiao   +10 more
doaj   +1 more source

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas, Jhamb, Deepali, Rajpal, Deepak K, Shu, Le, Yang, Xia, Zhao, Yuqi   +5 more
core   +3 more sources

Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes

Hereditas, 2022
Background Ancestry informative markers are regarded as useful tools for inferring the ancestral information of an individual, which have been widely used in the criminal investigations and population genetic studies.
Wei Cui, Shengjie Nie, Yating Fang, Man Chen, Ming Zhao, Qiong Lan, Chunmei Shen, Bofeng Zhu   +7 more
doaj   +1 more source

Multi-Omics Approaches in Immunological Research [PDF]

Frontiers in Immunology, 2021
The immune system plays a vital role in health and disease, and is regulated through a complex interactive network of many different immune cells and mediators. To understand the complexity of the immune system, we propose to apply a multi-omics approach in immunological research.
Xiaojing Chu, Xiaojing Chu, Xiaojing Chu, Bowen Zhang, Bowen Zhang, Valerie A. C. M. Koeken, Valerie A. C. M. Koeken, Valerie A. C. M. Koeken, Manoj Kumar Gupta, Manoj Kumar Gupta, Yang Li, Yang Li, Yang Li, Yang Li   +13 more
openaire   +4 more sources

Development and validation of a risk prediction model for overall survival in patients with nasopharyngeal carcinoma: a prospective cohort study in China

Cancer Cell International, 2022
Objective Nasopharyngeal carcinoma (NPC) is prevailing in Southern China, characterized by distinct geographical distribution. Aimed to predict the overall survival (OS) of patients with nasopharyngeal carcinoma, this study developed and validated ...
Siwei Miao, Haike Lei, Xiaosheng Li, Wei Zhou, Guixue Wang, Anlong Sun, Ying Wang, Yongzhong Wu   +7 more
doaj   +1 more source