Results 61 to 70 of about 136,187 (283)

HPV specificity and multiple infections and association with cervical cytology in Chongqing, China: a cross-sectional study

BMC Infectious Diseases
Background It is important to assess the relationship between specific HPV genotype or multiple infection and cervical cytology. The protection provided by the HPV vaccine is type-specific, and the epidemiology feature of coinfections needs to be ...
Qinli Luo, Haiyan Zhang, Xianghua Zeng, Na Han, Zhen Ma, Hanyi Luo   +5 more
doaj   +1 more source

Haplotypic polymorphisms and forensic applications in Chinese Hunan Han population based on a series of Y-STR loci: a perspective of paternal inheritance

Annals of Human Biology, 2023
Background Hunan, a multinational province in China, possesses more than fifty ethnic groups, such as the Han, Yao, Tujia, Miao, and so on. Aims To evaluate the forensic efficiency of the novel panel and investigate the genetic relationships between ...
Ming Zhao, Wei Cui, Yunying Zhang, Qiong Lan, Bofeng Zhu   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease [PDF]

, 2016
The peptiCKDdb is a publicly available database platform dedicated to support research in the field of chronic kidney disease (CKD) through identification of novel biomarkers and molecular features of this complex pathology.
Fernandes, Marco, Filip, Szymon, Husi, Holger, Jankowski, Joachim, Krochmal, Magdalena, Mischak, Harald, Pontillo, Claudia, Vlahou, Antonia, Zoidakis, Jerome   +8 more
core   +3 more sources

SP0055 CLINICAL MULTI-OMICS [PDF]

Annals of the Rheumatic Diseases, 2019
It is becoming clear that the field of medicine needs to change to stay affordable. One way of doing that is by optimizing the patients journey with true personalized medicine approaches. In other words, how to give every patient the right drug, at the right moment for the optimal duration.
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Multi-omic Data Integration

, 2015
Stable, predictive biomarkers and interpretable disease signatures are seen as a signi cant step towards personalized medicine. In this per- spective, integration of multi-omic data com- ing from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strat- egy to reconstruct and analyse complex mul- ti-dimensional interactions ...
P Tieri, C Nardini, J Dent et al
openaire   +3 more sources

Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/ mTOR axis in metastatic pheochromocytoma/ paraganglioma [PDF]

, 2019
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar y los autores pertenecientes a la UAMPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that present variable outcomes.
Alvarez - Escola, Cristina, Calsina, Bruna   +1 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Systematic selections and forensic application evaluations of 111 individual identification SNPs in the Chinese Inner Mongolia Manchu group

Frontiers in Genetics, 2022
Single nucleotide polymorphism (SNP) possesses a promising application in forensic individual identification due to its wide distribution in the human genome and the ability to carry out the genotyping of degraded biological samples by designing short ...
Congying Zhao, Hui Xu, Yating Fang, Ming Zhao, Qiong Lan, Man Chen, Shuyan Mei, Bofeng Zhu, Bofeng Zhu, Bofeng Zhu   +9 more
doaj   +1 more source