Results 81 to 90 of about 136,187 (283)

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]

, 2020
A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D, Buchanan, Fiona KB, Cameron, David, Carter, Jasmine L, Coggins, Nicole B, Deng, Peter, Fink, Kyle D, Gonzalez, Casiana E, Halmai, Julian ANM, Halmai, Julian ANM, Lock, Samantha R, Nolta, Jan, O'Geen, Henriette, Segal, David J, Waldo, Jennifer J   +14 more
core   +1 more source

Goose multi-omics database: A comprehensive multi-omics database for goose genomics

Poultry Science
Multi-omics has helped elucidate the gene expression patterns and genomic variations closely associated with economically significant traits in geese. Despite the substantial genomic data generated through extensive goose studies, a unified platform for integrating these datasets is lacking.
Mingjiang Huang, Jiahe Sun, Jian Wang, Xiaoli Ye, Zhuping Chen, Xianzhi Zhao, Keshan Zhang, Lin Ma, Jiajia Xue, Yi Luo, Xianwen Wu, Haiwei Wang, Chao Wang, Zuohua Liu, Youhui Xie, Ying Chen, Qigui Wang, Yi Wang, Guangliang Gao   +18 more
openaire   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel

Hereditas
Background The use of compound markers has gained significant interest among forensic practitioners, due to their ability to enhance genetic marker polymorphisms by introducing new alleles.
Qinglin Liang, Qiong Lan, Qinglin Liu, Xiaolian Wu, Lisiteng Luo, Chunmei Shen, Bofeng Zhu   +6 more
doaj   +1 more source

Lignin engineering in forest trees [PDF]

, 2019
Wood is a renewable resource that is mainly composed of lignin and cell wall polysaccharides. The polysaccharide fraction is valuable as it can be converted into pulp and paper, or into fermentable sugars.
Alvarenga Chanoca, Alexandra, Boerjan, Wout, de Vries, Lisanne   +2 more
core   +1 more source

Visual analysis of multi-omics data

Frontiers in Bioinformatics
We present a tool for multi-omics data analysis that enables simultaneous visualization of up to four types of omics data on organism-scale metabolic network diagrams. The tool’s interactive web-based metabolic charts depict the metabolic reactions, pathways, and metabolites of a single organism as described in a metabolic pathway database for that ...
Austin Swart, Ron Caspi, Suzanne Paley, Peter D. Karp   +3 more
openaire   +3 more sources

Multi-omic data analysis using Galaxy

Nature Biotechnology, 2015
[Extract] Comprehensive multi-omic data acquisition has become a reality, largely driven by the availability of high-throughput sequencing technologies for genomes and transcriptomes1, and high-resolution mass spectrometry (MS)2,3 for the in-depth characterization of proteomes and metabolomes.
Jorrit Boekel, John M Chilton, Ira R Cooke, Peter L Horvatovich, Pratik D Jagtap, Lukas Käll, Janne Lehtiö, Pieter Lukasse, Perry D Moerland, Timothy J Griffin   +9 more
openaire   +5 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Forensic utilization of NGS-STRs and evaluation of system efficacy for different kinship identifications

Human Genomics
Background The accurate identification of complex kinship relationships remains a significant challenge in forensic practice. Traditional kinship identification methods, which primarily rely on length polymorphisms of short tandem repeats (STRs), often ...
Hui Xu, Hongbing Yao, Xi Yuan, Qiong Lan, Yifeng Lin, Xiaolian Wu, Qinglin Liang, Qinglin Liu, Lisiteng Luo, Bofeng Zhu   +9 more
doaj   +1 more source

Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings [PDF]

Characterization of disease-associated proteins improves our understanding of disease pathophysiology. Obtaining a comprehensive coverage of the proteome is challenging, mainly due to limited statistical power and an inability to verify hundreds of ...
Borràs, Daniel M., Frantzi, Maria, Jankowski, Vera, Janssen, Bart, Latosinska, Agnieszka, Makridakis, Manousos, Merseburger, Axel S., Mischak, Harald, Mullen, William, Vlahou, Antonia, Zoidakis, Jerome   +10 more
core   +1 more source