Results 21 to 30 of about 6,800,484 (255)

Roles of Syzygium in Anti-Cholinesterase, Anti-Diabetic, Anti-Inflammatory, and Antioxidant: From Alzheimer’s Perspective

Plants, 2022
Alzheimer’s disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, and oxidative stress.
Mira Syahfriena Amir Rawa, Mohd Khairul Nizam Mazlan, Rosliza Ahmad, Toshihiko Nogawa, Habibah A. Wahab   +4 more
doaj   +1 more source

Multi-Agent Distributed Optimal Control for Tracking Large-Scale Multi-Target Systems in Dynamic Environments

, 2022
This paper considers the problem of motion coordination for a multi-agent network whose goal is to track a large-scale multi-target system in a region populated by dynamic obstacles.
Efstathios Bakolas (12868274), Alaa Abdulghafoor (12868232)   +1 more
core   +1 more source

The Antidiabetic Mechanisms of Cinnamon Extract: Insights from Network Pharmacology, Gut Microbiota, and Metabolites

Current Issues in Molecular Biology
The progression of type 2 diabetes mellitus (T2DM) is shaped by a multifaceted interplay among genetic, behavioral, and environmental factors, alongside gut dysbiosis.
Rong Wang, Kuan Yang, Xuefeng Liu, Yiye Zhang, Yunmei Chen, Nana Wang, Lili Yu, Shaojing Liu, Yaqi Hu, Bei Qin   +9 more
doaj   +1 more source

Multi-source Multi-target Domain Adaptation Based on Evidence Theory [PDF]

Domain adaptation usually confronts the multiple source and multiple target domains issue. In such case, the reduction of distribution discrepancy across domains and the combination of information in diverse domains are two major subproblems.
Fan, Jinfu, Wang, Shilin, Huang, Linqing, Liew, Alan Wee-Chung   +3 more
core   +1 more source

Bioactive Component Screening and Mechanistic Study of the Anti-Diabetic Activity of Lophatherum gracile Brongn Extract

Current Issues in Molecular Biology
Type 2 diabetes mellitus (T2DM), a metabolic disorder defined by glucose and lipid metabolism dysregulation, has become a major global health issue. Hence, effective measures to prevent T2DM are urgently required.
Rong Wang, Xuefeng Liu, Kuan Yang, Shaojing Liu, Lili Yu, Yunmei Chen, Nana Wang, Yaqi Hu, Bei Qin   +8 more
doaj   +1 more source

Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability

Current Issues in Molecular Biology
Background/Objectives: Gypenosides (Gps) are the main active compounds of Gynostemma and show promise in managing diabetes; nevertheless, the mechanism by which Gps exert anti-diabetic effects is still not fully understood.
Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin   +8 more
doaj   +1 more source

The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach

Frontiers in Pharmacology, 2020
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, yet as of currently, there is no disease-modifying therapy that could delay its progression. Paeonia lactiflora Pall.
Wanqing Du, Wanqing Du, Xiao Liang, Shanze Wang, Philip Lee, Yunling Zhang, Yunling Zhang   +6 more
doaj   +1 more source

Customizably designed multibodies neutralize SARS-CoV-2 in a variant-insensitive manner

Frontiers in Immunology, 2023
The COVID-19 pandemic evolves constantly, requiring adaptable solutions to combat emerging SARS-CoV-2 variants. To address this, we created a pentameric scaffold based on a mammalian protein, which can be customized with up to 10 protein binding modules.
Cecilia Abreu, Claudia Ortega, Natalia Olivero-Deibe, Federico Carrión, Aracelly Gaete-Argel, Aracelly Gaete-Argel, Fernando Valiente-Echeverría, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Ricardo Soto-Rifo, Rafaela Milan Bonotto, Alessandro Marcello, Sergio Pantano   +12 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A

Pharmaceuticals
(1) Background: Nifuratel (NF113), derived from nitrofuran, has a specific anti-tumor effect. However, the potential mechanisms of NF113 in triple-negative breast cancer remain unknown.
Yuhang Hou, Hongyun Hao, Yan Yuan, Jing Zhang, Zhengrui Liu, Yimin Nie, Shichang Zhang, Shengtao Yuan, Mei Yang   +8 more
doaj   +1 more source