Results 171 to 180 of about 76,878 (276)

Pictet–Spengler-Based Multicomponent Domino Reactions to Construct Polyheterocycles

Pharmaceutical Fronts, 2023
Jun-Duo Hu, Li-Liang Huang, Huang-Di Feng   +2 more
doaj   +1 more source

Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions. [PDF]

Antibiotics (Basel), 2023
Trejo A, Masdeu C, Serrano-Pérez I, Pedrola M, Juanola N, Ghashghaei O, Jiménez-Galisteo G, Lavilla R, Palacios F, Alonso C, Viñas M.   +10 more
europepmc   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Estimation of multicomponent reactions' yields from networks of mechanistic steps. [PDF]

Nat Commun
Szymkuć S, Wołos A, Roszak R, Grzybowski BA.   +3 more
europepmc   +1 more source

Copper-catalyzed multicomponent reactions for the efficient synthesis of diverse spirotetrahydrocarbazoles. [PDF]

Beilstein J Org Chem, 2022
Zhan SC, Fang RJ, Sun J, Yan CG.
europepmc   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Aryl glyoxal: a prime synthetic equivalent for multicomponent reactions in the designing of oxygen heterocycles. [PDF]

RSC Adv
Sheikh AR, Arif A, Khan MM.
europepmc   +1 more source

In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates. [PDF]

Molecules, 2022
Neto BAD, Beck PS, Sorto JEP, Eberlin MN.   +3 more
europepmc   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Retraction: Aryl glyoxal: a prime synthetic equivalent for multicomponent reactions in the designing of oxygen heterocycles. [PDF]

RSC Adv
Sheikh AR, Arif A, Khan MM.
europepmc   +1 more source