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Multidrug resistant tuberculosis. [PDF]

open access: yesBMJ, 2015
Tuberculosis remains a major cause of morbidity and mortality globally, with an estimated nine million people developing the disease and 1.5 million deaths in 2013; equating to 4100 deaths a day.1 Nevertheless, considerable gains have been made in ...
Millard, James   +2 more
core   +4 more sources

Multidrug resistant Acinetobacter

open access: yesJournal of Global Infectious Diseases, 2010
Emergence and spread of Acinetobacter species, resistant to most of the available antimicrobial agents, is an area of great concern. It is now being frequently associated with healthcare associated infections.
Vikas Manchanda   +2 more
doaj   +3 more sources

Multidrug Resistance

open access: yesAnnual Review of Medicine, 1991
Laboratory investigations indicate that cancer cells can become simultaneously resistant to many different chemotherapeutic drugs that are natural products via the expression of an energy-dependent drug efflux pump. This multidrug transporter is a plasma membrane glycoprotein encoded in the human by the MDR1 gene.
I, Pastan, M M, Gottesman
  +9 more sources

Multidrug-resistant tuberculosis [PDF]

open access: yesThe Lancet, 2019
The ideal number of drugs needed and treatment duration are crucial issues in the management of multidrug-resistant tuberculosis (MDR-TB). Thus, we read with interest the Article by the Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017,1 the results of which support our proposal,2 from 2015, to classify anti ...
Bern-Thomas, Nyang'wa   +3 more
  +10 more sources

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

open access: yesMicrobiology Spectrum, 2023
An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of ...
Ting L. Luo   +6 more
doaj   +1 more source

A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network

open access: yesGenome Medicine, 2022
Background Extra-intestinal pathogenic Escherichia coli (ExPEC) are a leading cause of bloodstream and urinary tract infections worldwide. Over the last two decades, increased rates of antibiotic resistance in E.
Emma G. Mills   +14 more
doaj   +1 more source

Detection of OXA-181-producing Pseudomonas aeruginosa in Germany

open access: yesInternational Journal of Medical Microbiology, 2022
Objectives: To report the detection of the class D carbapenemase OXA-181 in an MDR clinical Pseudomonas aeruginosa isolate in Germany. Methods: Carbapenemase detection was performed by using several phenotypic tests such as the modified Hodge test, a ...
Jennifer Schauer   +4 more
doaj   +1 more source

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. [PDF]

open access: yes, 2013
Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania.
Boeree, Martin J   +9 more
core   +11 more sources

Mechanisms of IS26-Mediated Amplification of the aphA1 Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate

open access: yesMicrobiology Spectrum, 2022
Enhanced levels of resistance to antibiotics arising from amplification of an antibiotic resistance gene that impact therapeutic options are increasingly observed. Amplification can also disclose novel phenotypes leading to treatment failure.
Christopher J. Harmer   +4 more
doaj   +1 more source

Multidrug resistance associated proteins in multidrug resistance [PDF]

open access: yesChinese Journal of Cancer, 2012
Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance
Sodani, Kamlesh   +3 more
openaire   +2 more sources

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