Results 111 to 120 of about 306,632 (271)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2‐Deoxyglucose

Angewandte Chemie, EarlyView.
New approaches to combat antimicrobial‐resistant pathogens are needed. Here, scaffolding a nonmetabolizable sugar (2DG) on a polymer backbone is shown to significantly improve its antimicrobial activity. ABSTRACT With the increasing prevalence of multidrug‐resistant (MDR) pathogens, last‐line therapeutics such as cyclic peptides are insufficient ...
Sungjin Jeon, Xianjin Qin, Marjon Zamani, Ariel L. Furst, Cassandra E. Callmann   +4 more
wiley   +2 more sources

In vitro activity of ceftazidime/avibactam against ceftazidime-resistant Enterobacterales and Pseudomonas aeruginosa from hospitalised patients in Germany

Journal of Global Antimicrobial Resistance, 2021
Michael Kresken, Miriam Korte-Berwanger, Niels Pfennigwerth, Sören G. Gatermann   +3 more
doaj   +1 more source

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Unveiling a hidden threat: whole genome sequencing exposes the cross-hospital spread of extensively drug-resistant Pseudomonas aeruginosa

Frontiers in Microbiology
IntroductionWhole genome sequencing (WGS) was performed on 10 extensively drug-resistant (XDR) Pseudomonas aeruginosa ST235 isolates to investigate potential healthcare-associated transmission of XDR P. aeruginosa ST235 within a U.S.
Edwin Kamau, Brendan Jones, Tatdanai Kitjawat, Han Ha Youn, Michael J. Schweikert, Angela Caldwell, Christopher Harens, Patrick T. Kiernan, John Mark Velasco, John Mark Velasco, Francois Lebreton, Nathanial K. Copeland   +11 more
doaj   +1 more source

Methicillin-Resistant Staphylococcus aureus as a Probable Cause of Antibiotic-Associated Enterocolitis

Case Reports in Infectious Diseases, 2018
Antibiotic-associated diarrhea is typically associated with Clostridium difficile. However, Staphylococcus aureus has also been described as a cause of antibiotic-associated enterocolitis and diarrhea and is likely an underrecognized etiology. We present
Alison B. Lane, Nathanial K. Copeland, Fatma Onmus-Leone, James V. Lawler   +3 more
doaj   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

SARS-CoV-2 infections in patients, health care workers and hospital outbreaks during the first 3 waves of the pandemic: a retrospective analysis in a secondary care hospital network in Germany

BMC Infectious Diseases
Background Hospital infections with SARS-CoV-2 continued during the initial waves of the pandemic worldwide. So far, Data on the dynamics of these infections and the economic burden of outbreaks are rare.
Anke Hildebrandt, Kirsten Dolega, Lutz Uflacker, Henrik Rudolf, Sören G. Gatermann   +4 more
doaj   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source