Results 121 to 130 of about 181,836 (261)

Routine immunization uptake and timeliness in young children exposed to multidrug-resistant tuberculosis: A secondary analysis of the Tuberculosis Child Multidrug-Resistant Preventive Therapy multi-site randomised controlled trial. [PDF]

BMC Glob Public Health
Patel F, Purchase S, Dhar M, Horne E, Grab J, Soma-Kasiram H, Sabet N, Martinson N, Staples S, Brigden J, Wilkinson T, Schaaf HS, Seddon J, Fairlie L, Hesseling A, Duong T.   +15 more
europepmc   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Total Synthesis of Sacrolide A and Cytotoxic Evaluation

European Journal of Organic Chemistry, EarlyView.
Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria, Kamel Hadj‐Kaddour, Alexis Giraudon, Jawad Belkheir, Alexandre Guy, Thierry Durand, Magali Gary‐Bobo, Camille Oger   +7 more
wiley   +1 more source

Nanoparticle-Based Strategies to Combat Multidrug-Resistant Bacteria: Mechanisms, Applications, and Future Perspectives. [PDF]

Microbiologyopen
Zubair A, Batool SZ, Helal MH, Afghan N.
europepmc   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Preventing Multidrug-Resistant Tuberculosis: The Dawn of a New Era. [PDF]

Clin Infect Dis
Churchyard GJ, Swindells S, Gupta A, Shah NS, Hughes M, Kim S, Fox GJ, Harrington M, Chaisson RE, Hesseling AC.   +9 more
europepmc   +1 more source

Antibacterial Hydrogel Dressing With Ca2+‐Dependent Hyaluronidase Responsiveness for Accelerating Wound Healing via On‐Demand Release of AIE Photosensitizers

Exploration, EarlyView.
This study innovates a Ca2+‐responsive hydrogel dressing that releases AIE photosensitizers on‐demand. Low Ca2+ enhances bacterial hyaluronidase (HAase) activity, degrading hyaluronic acid dressing to trigger antibacterial ROS release, while high Ca2+ inhibits HAase, preventing overdosing.
Rongwei Cui, Hao Yang, Miaomiao Kang, Zhijun Zhang, Weilin Xu, Yang Jiang, Lizhou Xu, Xiao‐Yong Zhan, Luhan Zhang, Yunsheng Xu, Dong Wang, Ben Zhong Tang, Danyang Li   +12 more
wiley   +1 more source

Recurrent Pneumothorax With Bronchopleural Fistula in Primary Multidrug-Resistant Pulmonary Tuberculosis: A Challenging Case. [PDF]

Respirol Case Rep
Primawati, Koesoemoprodjo W, Rizki M.
europepmc   +1 more source

Aloe vera in Food Preservation: Harnessing Bioactive Constituents for Clean‐Label Innovation and Safety Assurance

Food Safety and Health, EarlyView.
Aloe vera‐derived biopolymers and nanoformulations enhance antimicrobial, antioxidant, and barrier functions in clean‐label edible coatings and films, whereas safety‐critical anthraquinone thresholds and regulatory constraints shape their translational potential.
Acharya Balkrishna, Hemant Sharma, Sonam Verma, Amar Jeet, Sumit Kumar Singh, Sharad Kumar Tripathi, Vedpriya Arya   +6 more
wiley   +1 more source

An aryloxyphenol potentiates polymyxin against multidrug-resistant <i>Acinetobacter baumannii</i>. [PDF]

Front Cell Infect Microbiol
Lee K, Kim Y, Lee Y, Lee Y, Kwak J, Kim SY, Kim JS, Ryu CM, Seo HW, Kim D.   +9 more
europepmc   +1 more source