Results 131 to 140 of about 1,009,118 (297)

Multidrug-resistant malaria and the impact of mass drug administration

, 2018
Janie Anne Zuber, Shannon Takala-Harrison Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA Abstract: Based on the emergence and spread throughout the Greater Mekong Subregion (GMS ...
Zuber JA, Takala-Harrison S
core  

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris

Angewandte Chemie, EarlyView.
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger   +8 more
wiley   +2 more sources

Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion

Nature Communications
Human gut colonization by multi-drug resistant Enterobacterales (MDR-E) poses a risk for subsequent infections. Because of the collateral damage antibiotics cause to the microbiota, microbiome-based interventions aimed at promoting decolonization have ...
Marie Wende, Lisa Osbelt, Lea Eisenhard, Till Robin Lesker, Bamu F. Damaris, Uthayakumar Mutukumarasamy, Agata Bielecka, Éva d. H. Almási, Katrin Anja Winter, Jennifer Schauer, Niels Pfennigwerth, Sören Gatermann, Katharina Schaufler, Dirk Schlüter, Marco Galardini, Till Strowig   +15 more
doaj   +1 more source

A Novel Combination Regimen for the Treatment of Refractory Bacteremia Due to Multidrug-Resistant Pseudomonas Aeruginosa in a Liver Transplant Recipient

, 2011
P>Both bacteremia and biliary cast syndrome are serious post -transplant complications in liver transplant recipients. In the setting of increasing drug resistance in the current era, management of infections caused by multidrug-resistant( MDR) bacteria ...
孫幸筠, SUN, HSIN-YUN
core  

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

The nucleotide binding domains of multidrug resistance-p-glycoproteins [PDF]

, 2001
Bibliography: leaves 116 ...
De Wet, Heidi
core   +1 more source

ORAL COMMUNICATION | Frailty as an independent risk factor for multidrug-resistant bacterial infections in hospitalized older adults: an observational study

Italian Journal of Medicine
Introduction. Multidrug-resistant (MDR) bacterial infections are an emerging threat in older patients, but the role of global frailty, beyond age and comorbidity, has not been fully clarified. Materials and Methods. We conducted an observational study
C. Siniscalchi, A. Guerra, N. Cerundolo, B. Prati, E. Bazzani, A. Parise, A. Nouvenne, M. Basile, A. Cortenova, T. Meschi   +9 more
doaj   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

A new roadmap for childhood tuberculosis

The Lancet Global Health, 2014
Colleen D Acosta, Valiantsin Rusovich, Anthony D Harries, Sevim Ahmedov, Martin van den Boom, Masoud Dara   +5 more
doaj   +1 more source