Results 91 to 100 of about 37,118 (221)

Evaluation of the efficacy of RUTI and ID93/GLA-SE vaccines in tuberculosis treatment: in silico trial through UISS-TB simulator [PDF]

open access: yesarXiv, 2019
Tuberculosis (TB) is one of the deadliest diseases worldwide, with 1,5 million fatalities every year along with potential devastating effects on society, families and individuals. To address this alarming burden, vaccines can play a fundamental role, even though to date no fully effective TB vaccine really exists.
arxiv  

Multidrug-resistant tuberculosis

open access: yesBrazilian Journal of Infectious Diseases, 2013
Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although
Antônio Carlos Moreira Lemos   +1 more
doaj   +4 more sources

Determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in Tigray Region, Ethiopia: a case–control study

open access: yesBMJ Open Respiratory Research
Background Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first-line antituberculosis drugs namely, rifampicin and isoniazid. However, most of these studies were limited only to a single hospital.
Kidane Zereabruk   +6 more
doaj   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

open access: yesChemMedChem, Volume 20, Issue 10, May 19, 2025.
Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward   +9 more
wiley   +1 more source

Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes

open access: yesChemMedChem, Volume 20, Issue 9, May 5, 2025.
This review focus on the use of transition metal cross‐coupling strategies for the synthesis of beta‐lactam derivatives. This manuscript encompasses the seminal studies for the synthesis of antibiotics up to the current need of accessing specific probes that are crucial for the detection of resistances.
Jules Bresson   +4 more
wiley   +1 more source

Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients

open access: yesBrazilian Journal of Infectious Diseases, 2016
Background: Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors ...
Nafees Ahmad   +5 more
doaj  

Pulmonary Tuberculosis Edge Diagnosis System Based on MindSpore Framework: Low-cost and High-precision Implementation with Ascend 310 Chip [PDF]

open access: yesarXiv
Pulmonary Tuberculosis (PTB) remains a major challenge for global health, especially in areas with poor medical resources, where access to specialized medical knowledge and diagnostic tools is limited. This paper presents an auxiliary diagnosis system for pulmonary tuberculosis based on Huawei MindSpore framework and Ascend310 edge computing chip ...
arxiv  

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