Results 201 to 210 of about 365,495 (322)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Novel Adamantane-Sclareol Hybrids Exploit ROS Vulnerability to Overcome Multidrug-Resistance in Glioblastoma Cells. [PDF]

Molecules
Lupšić E, Stojković P, Grozdanić M, Terzić-Jovanović N, Pajović M, Koutsougianni F, Alexopoulou D, Opsenica IM, Pešić M, Podolski-Renić A.   +9 more
europepmc   +1 more source

STUDIO DELLA MULTIDRUG RESISTANCE NELLE SINDROMI LINFOPROLIFERATIVE

, 1991
Daniela Damiani, Angela Michelutti, Mariagrazia Michieli, Antonella Geromin, Donatella Raspadori, Mauro Giacca, Franco Mallardi, Michele Baccarani   +7 more
openalex   +1 more source

Effects of rhinacanthin-C in multidrug-resistance breast cancer cells [PDF]

, 2019
Suwichak Chaisit
openalex   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Genetic diversity, genetic population structure and epidemiology of multidrug resistance Neisseria gonorrhoeae from Kenya. [PDF]

PLoS One
Musee HK, Mukhebi DW.
europepmc   +1 more source

Plasmid Profile, Curing Analysis, and antibacterial Activity of Alcea arebellensis plant Against Multidrug Resistance Staphylococcus aureus

, 2023
Zirak F.A. Abdulrahman, Khadija Kh. Barzani, Aryan A. Rasheed   +2 more
openalex   +2 more sources

Oxidative Treatment for Reducing Persistent Populations of Escherichia coli Under Amoxicillin and Gentamicin Pressure

Journal of Biophotonics, EarlyView.
Photodynamic inactivation (PDI) with methylene blue and 660 nm LED enhances antibiotic killing of bacteria, accelerating time‐kill kinetics and reducing the MDK99 compared to antibiotics alone. SEM confirms effective cellular damage, demonstrating that PDI potentiates amoxicillin and gentamicin against tolerant bacterial populations. ABSTRACT Bacterial
Bruna C. Correa, Maria Vitória S. Pereira, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma. [PDF]

Cancer Drug Resist
Codenotti S, Marampon F, Megiorni F, Cattaneo CG, Gastaldello S, Pozzo E, Sampaolesi M, Rota R, Keller C, Fanzani A.   +9 more
europepmc   +1 more source

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, EarlyView.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source