Results 1 to 10 of about 578,414 (184)
Overcoming multiple drug resistance mechanisms in medulloblastoma [PDF]
Acta Neuropathologica Communications, 2014 Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumvention of chemoresistance pathways (drug export, DNA repair and apoptotic inhibition) can restore chemotherapeutic efficacy in a panel of MB cell ...
Othman, Ramadhan T. +8 more
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Management of multiple drug-resistant tuberculosis
Respiratory Medicine, 2003 There has been a worldwide increase in multiple drug-resistant tuberculosis (MDR-TB) which has in the past been associated with a poor prognosis. In the U.K., about half of the cases live in the London area and we have set out to obtain further information on their treatment and outcome.
Hutchison, D C S +2 more
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Molecular mechanisms in multiple myeloma drug resistance [PDF]
Journal of Clinical Pathology, 2015 Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage.
Nikesitch, Nicholas (S31628) +1 more
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Biomarkers and Multiple Drug Resistance in Breast Cancer [PDF]
Current Cancer Drug Targets, 2006 Breast cancer, the most common form of cancer among women in North America and almost all of Europe, is a significant health problem in terms of both morbidity and mortality. It is estimated that each year this disease is diagnosed in over one million people worldwide and is the cause of more than 400,000 deaths.
Lorraine O'Driscoll, Martin Clynes
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Evolution of multiple drug resistance in staphylococci [PDF]
Microbiology Australia, 2008 Since the dawn of the era of antibiotic therapy, beginning with the introduction of the first penicillins ( -lactams) in the 1940s, strains of Staphylococcus aureus exhibiting resistance to antibiotics have become more and more prevalent in both clinical and community settings.
Jensen, Slade O. +3 more
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Management of Multiple Drug-Resistant Infections [PDF]
Journal of Antimicrobial Chemotherapy, 2004 Part I: Gram-Positive Bacteria Management of Community-Acquired Pneumonia Caused by Drug-Resistant Streptococcus pneumoniae Eric L. Nuermberger and William R. Bishai Management of Meningitis Caused by Resistant Streptococcus pneumoniae P. Fernandez Viladrich Emerging Resistance to Vancomycin, Rifampin, and Fluoroquinolones in Streptococcus pneumoniae ...
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Multiple drug resistance in Candida albicans.
Acta Biochimica Polonica, 1995 By functional complementation of a PDR 5 (pleiotropic drug resistance) null mutant of S. cerevisiae, we have recently cloned and sequenced a multidrug resistance gene CDR 1 (Candida Drug Resistance). Transformation by CDR 1 of a PDR 5 disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to these as well as other ...
R, Prasad +3 more
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The evolution of multiple drug resistance in malaria parasites
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1998 Forces determining the rate of spread of drug resistance in malaria were explored using a genetics transmission model which took account of the strong population structure of these parasites. The rate of change of frequency of drug resistant mutants in the parasite population is primarily a function of the proportion of hosts treated with drugs, and ...
Mackinnon, M, Hastings, I
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Multiple drug resistant tuberculosis. [PDF]
Journal of Clinical Pathology, 1997 Francis Drobniewski, M Yates
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