Results 91 to 100 of about 677,678 (301)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Conservatism implications of shock test tailoring for multiple design environments [PDF]

A method for analyzing shock conservation in test specifications that have been tailored to qualify a structure for multiple design environments is discussed.
Baca, Thomas J., Bell, R. Glenn, Robbins, Susan A.   +2 more
core   +1 more source

Enhancing the EAST-ADL error model with HiP-HOPS semantics [PDF]

, 2014
EAST-ADL is a domain-specific modelling language for the engineering of automotive embedded systems. The language has abstractions that enable engineers to capture a variety of information about design in the course of the lifecycle — from requirements ...
Chen, De-Jiu, Lönn, Henrik, Papadopoulos, Yiannis, Sharvia, Septavera, Walker, Martin, Yuan, Wenjing   +5 more
core  

Instant restore after a media failure

, 2017
Media failures usually leave database systems unavailable for several hours until recovery is complete, especially in applications with large devices and high transaction volume.
C Mohan, C Mohan, E Levy, G Graefe, G Graefe, J Gray, JN Gray, PM Chen, T Härder   +8 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Safety factor probabilistic design of composite structures based on reliability

Xibei Gongye Daxue Xuebao
Deterministic safety factor design is difficult to adapt to the characteristics of composite structures with many uncertainty factors and concurrent multiple failure modes, and the design results cannot quantitatively describe the level of risk.
FENG Yunwen, SONG Zhicen, CHEN Hongzhi, CHEN Xianmin, XUE Xiaofeng, HU Hao   +5 more
doaj   +1 more source

Compression of thick laminated composite beams with initial impact-like damage [PDF]

While the study of compression after impact of laminated composites has been under consideration for many years, the complexity of the damage initiated by low velocity impact has not lent itself to simple predictive models for compression strength.
Breivik, N. L., Griffin, O. H., Jr., Guerdal, Z.   +2 more
core   +1 more source

Fault detection, identification and accommodation techniques for unmanned airborne vehicles [PDF]

, 2005
Unmanned Airborne Vehicles (UAV) are assuming prominent roles in both the commercial and military aerospace industries. The promise of reduced costs and reduced risk to human life is one of their major attractions, however these low-cost systems are yet ...
Cork, Lennon, Dunn, Shane, Walker, Rodney   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Multiple Failure Modes，Causes and Prevention of Random Fracture for Hard Tooth Flank Gears

Jixie chuandong, 2022
The history and evolution of the random fracture terms，the morphological features，failure examples，causes and preventive measures of various random fracture modes are comprehensively discussed.
Xiaolu Zhu
doaj