Results 61 to 70 of about 677,678 (301)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

RESEARCH ON MULTIPLE FAILURE MODES FOR RELIABILITY CALCULATION IN CRACK GROWTH LIFE BY SQP METHOD

Jixie qiangdu, 2019
The fatigue crack growth（FCG） phenomenon always exists in large mechanical structural. Influenced by varied kinds of random factors, the safety evaluation of structure in FCG is under great uncertainty.
SUN YuanTao, ZHANG ZengZeng, ZHANG Qing, QIN XianRong   +3 more
doaj  

System Reliability Assessment for a Rock Tunnel with Multiple Failure Modes

Rock Mechanics and Rock Engineering, 2012
This paper presents a practical procedure for assessing the system reliability of a rock tunnel. Three failure modes, namely, inadequate support capacity, excessive tunnel convergence, and insufficient rockbolt length, are considered and investigated using a deterministic model of ground-support interaction analysis based on the convergence–confinement
Lü, Qing, Chan, Chin Loong, Low, Bak Kong   +2 more
openaire   +3 more sources

Proactive risk assessment of vincristine use process in a teaching and referral hospital in Kenya [PDF]

, 2018
Background: The chemotherapy use process is considered as potentially risky for cancer patients due to its complex process, use of agents with narrow therapeutic indeces, multiple drug use and use of potentially toxic compounds adding to morbidity and ...
Godman, B., Guantai, A. N., Kurdi, A., Kurgat, E. Kipkurui, Wata, D, Weru, I.   +5 more
core  

The integration of on-line monitoring and reconfiguration functions using IEEE1149.4 into a safety critical automotive electronic control unit. [PDF]

, 2005
This paper presents an innovative application of IEEE 1149.4 and the integrated diagnostic reconfiguration (IDR) as tools for the implementation of an embedded test solution for an automotive electronic control unit, implemented as a fully integrated ...
Cutajar, R., Jeffery, C., Lickess, M., Prosser, S., Richardson, Andrew M. D., Riches, S.   +5 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

An efficient hybrid reliability analysis method with application to the harmonic drive.

PLoS ONE
The harmonic drive is a new type of high-efficiency gear transmission system, widely used in precision machinery, robotics, and aerospace due to its compact structure and high transmission accuracy, and the multiple uncertain parameters in it will ...
Jingqi Cui, Di Zuo, Xiaoxi Men, Chongshuai Wang   +3 more
doaj   +1 more source

Reliability Analysis of High-Pressure Tunnel System Under Multiple Failure Modes Based on Improved Sparrow Search Algorithm–Kriging–Monte Carlo Simulation Method

Applied Sciences
It is often difficult for a structural safety design method based on deterministic analysis to fully and reasonably reflect the randomness of mechanical parameters, while the traditional reliability analysis method has a large calculation cost and low ...
Yingdong Wang, Chen Xing, Leihua Yao
doaj   +1 more source

Failure Test and Finite Element Simulation of a Large Wind Turbine Composite Blade under Static Loading

Energies, 2014
This study presented a failure analysis of a 52.3 m composite wind turbine blade under static loading. Complex failure characteristics exhibited at the transition region of the blade were thoroughly examined and typical failure modes were indentified. In
Xiao Chen, Wei Zhao, Xiao Lu Zhao, Jian Zhong Xu   +3 more
doaj   +1 more source