Results 181 to 190 of about 351,954 (346)

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

The SCARLET Trial: Radiotheranostics in Multiple Myeloma. [PDF]

Radiol Imaging Cancer
Jain S, Graham MM.
europepmc   +1 more source

A Model‐Based Meta‐Analysis of Pembrolizumab Effects on Patient‐Reported Quality of Life: Advancing Patient‐Centered Oncology Drug Development

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pembrolizumab is an immune checkpoint inhibitor that has been approved for more than 20 different indications and has shown great survival benefits in various types of cancer. However, the reported benefits of pembrolizumab in patients' quality of life (QoL) have been inconsistent across different studies and different types of cancer.
Yiqin Zou, Yimeng Sun, Sudhamshu Ravva, Lynne I. Wagner, Jiawei Zhou   +4 more
wiley   +1 more source

Efficacy of melflufen in multiple myeloma with mutated or deleted TP53. [PDF]

Exp Hematol Oncol
Acs K, Miettinen JJ, Sergeev P, Heckel T, Diao Y, Witt-Mulder K, Thureson M, Bischler T, Huppunen ME, Suvela M, Obermüller J, Munawar U, Slipicevic A, Bargou RC, Lehmann F, Gelius SS, Norin S, Schjesvold F, Sonneveld P, Stühmer T, Heckman CA.   +20 more
europepmc   +1 more source

Integrating MBMA and QSP to Identify Key Covariates and Predict Treatment Outcomes in Relapsed/Refractory Multiple Myeloma

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT This study demonstrates the application of a model based meta analysis (MBMA) framework to characterize the safety and efficacy profiles of therapies in relapsed and refractory multiple myeloma (RRMM). Published clinical trial data were analyzed to evaluate the incidence of Grade ≥ 3 neutropenia and overall response rate (ORR), providing a ...
Zeel Shah, Clifton M. Anderson, Kevin D. McCormick, Celeste Vallejo, William Duncan, Chuanpu Hu, Jian Zhou, Alexander V. Ratushny, Anna G. Kondic   +8 more
wiley   +1 more source

Redefining Cure in Multiple Myeloma: Are We Chasing a Moving Target? [PDF]

Health Sci Rep
Kitundu JH.
europepmc   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

CELMoD-antibody conjugates unlock a CD38 feedback loop in multiple myeloma. [PDF]

Acta Pharm Sin B
Jin J.
europepmc   +1 more source

ASSESSMENT OF NUTRITIONAL STATUS AND FREQUENCY OF MONOCLONAL ANTIBODIES IN PATIENTS WITH MULTIPLE MYELOMA SUBJECT TO CHEMOTHERAPY

, 2014
Messaoudi Houria, Mourad Aribi
openalex   +1 more source

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation

VIEW, EarlyView.
SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Zhehan Hu, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun   +11 more
wiley   +1 more source