Results 151 to 160 of about 56,774 (264)
Progress in RNA‐Targeted Therapeutics for Human Diseases
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu +4 more
wiley +1 more source
Abstract A 3‐year‐old, entire, male cocker spaniel presented for behavioural assessment following a 2.5‐year history of compulsive circling to the right‐hand side. It was previously diagnosed with meningomyelitis of unknown aetiology, following an acute onset of blindness in the left eye and decreased postural reactions.
Emma Gatehouse, Vera Pisco
wiley +1 more source
Examination of High-Level Language Skills in 2 Phases of Multiple Sclerosis (Relapsing-Remitting & Secondary Progressive) in Comparison With Healthy Counterparts. [PDF]
Rahimifar P +8 more
europepmc +1 more source
Abstract Importance Multiple sclerosis is a chronic neurological progressive disease that can lead to different impairments. It may also impact individuals' quality of life and daily living, including occupational performance and occupational balance. However, occupational balance has not been thoroughly described in this population.
Araceli Ortiz‐Rubio +3 more
wiley +1 more source
Unilateral optic neuritis and thinning of retinal layers in the affected and unaffected eyes
Abstract Purpose Multiple sclerosis (MS)‐related optic neuritis (ON) causes thinning of inner retinal layers. It remains unclear whether unilateral MSON also affects the unaffected contralateral eye. The purpose of this study was to compare macular retinal layer thicknesses in MS eyes with unilateral optic neuritis (MSON), their unaffected ...
Sanna Leinonen +4 more
wiley +1 more source
ABSTRACT Background and Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a chronic disorder with a relapsing–remitting disease course that impacts patients' quality of life. Oral glucocorticoids (OGCs) have been the standard of care for NMOSD in Japan; however, their chronic use is associated with adverse events (AEs).
Yuko Shimizu +7 more
wiley +1 more source
ABSTRACT Objectives Although satralizumab, an interleukin‐6 receptor inhibitor, effectively prevents relapses in neuromyelitis optica spectrum disorder (NMOSD), infections are reported to be the most common adverse reactions. To support Japanese patients receiving satralizumab, “Circle”—a 1‐year patient support program—was developed.
Kazuo Fujihara +3 more
wiley +1 more source
Therapeutic Outcomes of Fingolimod and Interferon Beta-1a in Relapsing-Remitting Multiple Sclerosis: A Real-World Study from Jordan. [PDF]
Al Anber A +6 more
europepmc +1 more source

