This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim +6 more
wiley +1 more source
Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. [PDF]
Ruppert E +9 more
europepmc +1 more source
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady +5 more
wiley +1 more source
Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters. [PDF]
Canna A +11 more
europepmc +1 more source
An update on multiple system atrophy. [PDF]
Stankovic I, Kuijpers M, Kaufmann H.
europepmc +1 more source
Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study. [PDF]
Liu PC +5 more
europepmc +1 more source
Characteristics of dysarthria in patients with spinocerebellar degeneration and multiple system atrophy: a cross-sectional and longitudinal study using the Frenchay Dysarthria Assessment Second Edition (FDA-2). [PDF]
Kawabata A +6 more
europepmc +1 more source
Autonomic dysfunction in multiple system atrophy: from pathophysiology to clinical manifestations. [PDF]
Luo Y +6 more
europepmc +1 more source
Brain structural features with functional priori to classify Parkinson's disease and multiple system atrophy using diagnostic MRI. [PDF]
Zhou K +9 more
europepmc +1 more source

