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Nature Reviews Disease Primers, 2022
Multiple system atrophy (MSA) is a rare neurodegenerative disease that is characterized by neuronal loss and gliosis in multiple areas of the central nervous system including striatonigral, olivopontocerebellar and central autonomic structures.
Werner Poewe +8 more
+6 more sources
Multiple system atrophy (MSA) is a rare neurodegenerative disease that is characterized by neuronal loss and gliosis in multiple areas of the central nervous system including striatonigral, olivopontocerebellar and central autonomic structures.
Werner Poewe +8 more
+6 more sources
Seminars in Neurology, 2014
Multiple system atrophy (MSA) is a rare adult-onset synucleinopathy associated with dysautonomia and the variable presence of poorly levodopa-responsive parkinsonism and/or cerebellar ataxia. Other clinical symptoms that can be associated with MSA include hyperreflexia, stridor, sleep apnea, and rapid eye movement sleep behavior disorder (RBD).
D. Robertson, M.C. Ferguson, A. Diedrich
+6 more sources
Multiple system atrophy (MSA) is a rare adult-onset synucleinopathy associated with dysautonomia and the variable presence of poorly levodopa-responsive parkinsonism and/or cerebellar ataxia. Other clinical symptoms that can be associated with MSA include hyperreflexia, stridor, sleep apnea, and rapid eye movement sleep behavior disorder (RBD).
D. Robertson, M.C. Ferguson, A. Diedrich
+6 more sources
The Lancet Neurology, 2004
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterised clinically by any combination of parkinsonian, autonomic, cerebellar, or pyramidal signs and pathologically by cell loss, gliosis, and glial cytoplasmic inclusions in several CNS structures.
Gregor K, Wenning +3 more
openaire +3 more sources
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterised clinically by any combination of parkinsonian, autonomic, cerebellar, or pyramidal signs and pathologically by cell loss, gliosis, and glial cytoplasmic inclusions in several CNS structures.
Gregor K, Wenning +3 more
openaire +3 more sources
Current Opinion in Neurology, 1995
The past year has seen advances in delineating the clinical features, natural history and imaging characteristics of multiple system atrophy. The initiating pathogenetic mechanisms remain unknown. However, any aetiological or pathophysiological hypothesis must consider not only neuronal loss and gliosis but also the recently described characteristic ...
N, Quinn, G, Wenning
openaire +4 more sources
The past year has seen advances in delineating the clinical features, natural history and imaging characteristics of multiple system atrophy. The initiating pathogenetic mechanisms remain unknown. However, any aetiological or pathophysiological hypothesis must consider not only neuronal loss and gliosis but also the recently described characteristic ...
N, Quinn, G, Wenning
openaire +4 more sources
The Neurologist, 2008
It has been almost 4 decades since the descriptions of the 3 parts of multiple system atrophy (MSA) have taken place, characterized clinically by dysautonomia, parkinsonism, and cerebellar dysfunction. The discovery of a distinctive pathologic maker has finally provided the conceptual synthesis of these 3 entities into the universal designation of MSA ...
Roongroj, Bhidayasiri, Helen, Ling
openaire +2 more sources
It has been almost 4 decades since the descriptions of the 3 parts of multiple system atrophy (MSA) have taken place, characterized clinically by dysautonomia, parkinsonism, and cerebellar dysfunction. The discovery of a distinctive pathologic maker has finally provided the conceptual synthesis of these 3 entities into the universal designation of MSA ...
Roongroj, Bhidayasiri, Helen, Ling
openaire +2 more sources
2005
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that usually manifests in the early fifties and progresses relentlessly with a mean survival of 9 years. Clinically, MSA is dominated by autonomic/urogenital failure which may be associated with either levodopa unresponsive parkinsonism in 80p.cent of cases (MSA-P subtype) or with ...
G K, Wenning, F, Geser
openaire +3 more sources
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that usually manifests in the early fifties and progresses relentlessly with a mean survival of 9 years. Clinically, MSA is dominated by autonomic/urogenital failure which may be associated with either levodopa unresponsive parkinsonism in 80p.cent of cases (MSA-P subtype) or with ...
G K, Wenning, F, Geser
openaire +3 more sources
Multiple system atrophy masking multiple sclerosis
Clinical Neurology and Neurosurgery, 2010Multiple system atrophy (MSA) and multiple sclerosis (MS) are progressive neurological disorders with overlapping clinical signs and symptoms. However, due to the course of the disease and the age of onset both disorders are rarely differential diagnosis for each other. We here report the remarkable association of the two diseases in one patient.
Carsten, Finke +4 more
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Progressive cerebral atrophy in multiple system atrophy
Journal of the Neurological Sciences, 2002Nine patients with multiple system atrophy (MSA) were studied based on MRI findings of cerebral hemispheric involvement. The age at onset was 56.4+/-8.6 (mean+/-S.D.) years, duration of illness at the first MRI study 2.1+/-1.1 years, duration of illness at the last study 9.7+/-2.6 years, and the follow-up duration 7.6+/-2.3 years.
Masaaki, Konagaya +4 more
openaire +2 more sources
2007
Publisher Summary This chapter deals with the epidemiology, clinical features, pathological characteristics, diagnostic evaluation, and treatment approaches for multiple system atrophy (MSA). MSA is regarded as a distinct disease process with a complex combination of clinical presentations.
openaire +2 more sources
Publisher Summary This chapter deals with the epidemiology, clinical features, pathological characteristics, diagnostic evaluation, and treatment approaches for multiple system atrophy (MSA). MSA is regarded as a distinct disease process with a complex combination of clinical presentations.
openaire +2 more sources