Results 71 to 80 of about 25,229 (229)

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response. [PDF]

, 2018
The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes.
Cheng, Zhi, Dong, Lei, Han, Ming-Yu, Huang, Zhong-Xi, Jiang, Tao, Li, Jin-Bang, Li, Xin, Li, Xin, Liu, Teng-Fei, Liu, Xiao, Long, Xiao-Bing, Lyu, Xiao-Ming, Qiu, Mo-Chang, Sun, Tao, Wang, Jia-Hong, Wang, Jian-Guo, Wang, Qian, Wang, Shuang, Wei, Gan-Guan, Yang, Xue-Xi, Yao, Kaitai, Zhang, Bo, Zhang, Long-Cheng, Zhao, Manli, Zheng, Hou-Feng, Zheng, Lu, Zhu, Xiao-Wei, Zuo, Xian-Bo   +27 more
core   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Contribution of time of day and the circadian clock to the heat stress responsive transcriptome in Arabidopsis. [PDF]

, 2019
In Arabidopsis, a large subset of heat responsive genes exhibits diurnal or circadian oscillations. However, to what extent the dimension of time and/or the circadian clock contribute to heat stress responses remains largely unknown.
Blair, Emily J, Bonnot, Titouan, Hay, Erika, Hummel, Maureen, Marzolino, Jill M, Nagel, Dawn H, Quijada, Ivan A   +6 more
core   +2 more sources

Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays

ALTEX, 2018
The mouse bioassay for the detection of marine biotoxins in shellfish products is 40 years old and still in use. A full ban or total replacement of this in vivo test has been postponed because of the fear that current chemical-based detection methods could miss a new emerging toxin.
Bodero, Marcia, Bovee, Toine F.H., Portier, Liza, Hendriksen, Peter J.M.   +3 more
openaire   +3 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Signalling with retinoids in the human lung: validation of new tools for the expression study of retinoid receptors. [PDF]

, 2009
International audienceBACKGROUND: Retinoid Receptors are involved in development and cell homeostasis. Alterations of their expressions have been observed in lung cancer.
Poulain, Stéphane, Lacomme, Stéphanie, Battaglia-Hsu, Shyue-Fang, Du Manoir, Stanislas, Brochin, Lydia, Vignaud, Jean-Michel, Martinet, Nadine   +6 more
core   +3 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Development of a quadruple qRT-PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance

BMC Infectious Diseases, 2018
Background During the fifth wave of human H7N9 infections, a novel highly pathogenic (HP) H7N9 variant emerged with an insertion of multiple basic amino acids in the HA cleavage site.
Yang Yang, Shanqin Li, Gary Wong, Sufang Ma, Zhixiang Xu, Xiaonan Zhao, Hong Li, Wen Xu, Haixia Zheng, Jingyan Lin, Qi Zhao, Wenjun Liu, Yingxia Liu, George F. Gao, Yuhai Bi   +14 more
doaj   +1 more source

Rapid typing diagnosis and clinical analysis of subtypes A and B of human respiratory syncytial virus in children

Virology Journal, 2022
Background Human respiratory syncytial virus (HRSV) is the leading pathogens causing acute respiratory infections (ARI) in children under five years old. We aimed to investigate the distribution of HRSV subtypes and explore the relationship between viral
Zheng Shen, Yuanyuan Zhang, Huamei Li, Lizhong Du   +3 more
doaj   +1 more source

Pregnancy Zone Protein Serves as a Prognostic Marker and Favors Immune Infiltration in Lung Adenocarcinoma

Biomedicines, 2023
Lung adenocarcinoma (LUAD) is a public enemy with a very high incidence and mortality rate, for which there is no specific detectable biomarker. Pregnancy zone protein (PZP) is an immune-related protein; however, the functions of PZP in LUAD are unclear.
Kehong Chen, Taihao Zheng, Cai Chen, Liangzhong Liu, Zhengjun Guo, Yuan Peng, Xiaoyue Zhang, Zhenzhou Yang   +7 more
doaj   +1 more source