Results 31 to 40 of about 283 (168)

Buckling‐Driven Linearity in Flexible Capacitive Pressure Sensors Based on a Three‐Dimensional Dual‐Pore Polyurethane Structure

open access: yesAdvanced Materials Technologies, EarlyView.
A flexible pressure sensor utilizing a 3D dual‐pore polyurethane structure is developed to overcome the intrinsic trade‐off between sensitivity and linearity. By inducing sequential buckling through distinct pore sizes and shapes, the device achieves highly linear and sensitive responses across a wide pressure range.
Jae Yeong Jang, Jaemin Choi, Young Jung
wiley   +1 more source

Exploring the relationship of higher order DNA mixtures using autosomal STR and Y chromosome STR multiplexes

open access: yes, 2022
Full Text is available to authenticated members of The University of Auckland only.Forensic laboratories like the Institute of Environmental Science and Research Ltd (ESR) are frequently tasked with sample analysis containing very low quantities of ...
Bush, Troy Shannon
core  

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

open access: yesAdvanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai   +15 more
wiley   +1 more source

Mise au point de deux tests PCR multiplexes pour détecter simultanément des formes recombinantes et non-recombinantes du Tomato yellow leaf curl virus au Maroc [PDF]

open access: yes, 2013
Le Tomato yellow leaf curl virus (TYLCV, genre Begomvirus, famille Geminiviridae) a été isolé pour la première fois au Maroc en 1998 (Peterschmitt et al., 1999) et le Tomato yellow leaf curl Sardinia virus (TYLCSV) en 1999 (Monci et al., 2000).
Tahiri, Abdessalem   +5 more
core  

Modified Midi- and Mini-Multiplex PCR Systems for Mitochondrial DNA Control Region Sequence Analysis in Degraded Samples

open access: yes, 2013
Two multiplex polymerase chain reaction (PCR) systems (Midiplex and Miniplex) were developed for the amplification of the mitochondrial DNA (mtDNA) control region, and the efficiencies of the multiplexes for amplifying degraded DNA were validated using ...
신경진   +3 more
core   +1 more source

Autosomal short tandem repeat (STR) profiling of human skeletal remains

open access: yes, 2023
This chapter introduces autosomal short tandem repeats (STRs) and their use as the most popular genetic marker for human identification. It explains the characteristics of STR loci that make them suitable for forensic use and lists the core STR loci ...
Ward, J, Watherston, J
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang   +16 more
wiley   +1 more source

Development of multiplex PCRs for evolutionary and forensic applications of 37 human Y chromosome SNPs

open access: yes, 2006
This work describes an efficient and rapid test for typing 37 single nucleotide polymorphisms (SNPs) of the non-recombining region of Y chromosome (NRY) from a minimal amount of DNA using six PCR multiplexes.
TAGLIABRACCI, Adriano   +5 more
core   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

open access: yesAdvanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch   +4 more
wiley   +1 more source

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