Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer [PDF]
Cancer Research, 2018 Abstract PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to targeting poly(ADP-ribose) generating PARP,
Zebin Wang +24 more
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Origin of the Cones of the Multipolar Spindle in Gladiolus [PDF]
Botanical Gazette, 1900 The above observations may be summarized as follows: As nuclear division approaches, a granular zone accumulates about the nucleus. This zone in every respect resembles the perikaryoplasm so characteristic of the pollen mother cells of Cobaea. A close network or felted zone of kinoplasmic fibers is formed immediately outside of and completely ...
ANSTRUTHER A. LAWSON
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Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach [PDF]
Cell Death & Disease, 2012 Centrosome amplification (CA) and resultant chromosomal instability have long been associated with tumorigenesis. However, exacerbation of CA and relentless centrosome declustering engender robust spindle multipolarity (SM) during mitosis and may induce cell death. Recently, we demonstrated that a noscapinoid member, reduced bromonoscapine, (S)-3-(R)-9-
Ram Chandra Mishra +9 more
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Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability [PDF]
Frontiers in Cell and Developmental Biology, 2021 Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly are, in turn, the major contributors to the error-prone nature of chromosome segregation in the oocytes of
Marilena Rizzo +6 more
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A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering [PDF]
Cell Death & Differentiation, 2010 We have previously shown that a non-toxic noscapinoid, EM011 binds tubulin without altering its monomer/polymer ratio. EM011 is more active than the parent molecule, noscapine, in inducing G2/M arrest, inhibiting cellular proliferation and tumor growth in various human xenograft models. However, the mechanisms of mitotic-block and subsequent cell death
Kamlesh K. Gupta +8 more
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PLoS ONE, 2008 Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution.
Gisselsson, D +8 more
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The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
PLoS ONEThe mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function ...
Renaldo Sutanto +6 more
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