OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival. [PDF]
EMBO RepCancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA screens of deubiquitinase enzymes, we identify OTUD6B as a positive regulator
Marotta VE +8 more
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Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification. [PDF]
Cancer Gene TherCentrosome amplification (CA), an abnormal increase in the number of centrosomes in the cell, is a recurrent phenomenon in lung and other malignancies.
Zhang C +14 more
europepmc +2 more sources
Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance [PDF]
Nature CommunicationsSSNA1 is a fibrillar protein involved in dynamic microtubule remodeling, including nucleation, co-polymerization, and microtubule branching. The underlying molecular mechanism has remained unclear due to a lack of structural information.
Lorenzo Agostini +7 more
doaj +2 more sources
Testicular Hypoplasia with Multipolar Spindle Formation in the Spermiocytes of the Bull [PDF]
Acta Veterinaria Scandinavica, 1961 Formation of multipolar nuclear spindles in spermiocytes has been demonstrated in three highly in-bred and closely related bulls with a type of testicular hypoplasia which can be summarised as arrested spermiogenesis. The spindle abnormality can be assumed to be the cause of the disturbance in spermiogenesis and to be associated with the formation of ...
O Knudsen
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Small Molecules Identified by an In Silico Docking Screen Targeting Anaphase-Promoting Complex/Cyclosome Subunit 1 (APC1) Potentiate Paclitaxel-Induced Breast Cancer Cell Death [PDF]
MoleculesDelaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar mitotic spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-
Scott C. Schuyler +4 more
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Disturbed chromosome segregation and multipolar spindle formation in a patient with
Molecular Genetics & Genomic Medicine, 2017 Patients with intellectual disability (ID) typically exhibit significant defects in both intelligence and adaptive behavior. Aberration of several genes involved in proper progression of mitosis has been reported to underlie ID. Here, we report a new patient with a novel mutation of CHAMP1.Whole exome sequencing (WES) analysis was performed.
Nobuhiko Okamoto +6 more
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MULTIPOLAR SPINDLE 1 (MPS1), a novel coiled‐coil protein of Arabidopsis thaliana, is required for meiotic spindle organization [PDF]
The Plant Journal, 2009 SummaryThe spindle is essential for chromosome segregation during meiosis, but the molecular mechanism of meiotic spindle organization in higher plants is still not well understood. Here, we report on the identification and characterization of a plant‐specific protein, MULTIPOLAR SPINDLE 1 (MPS1), which is involved in spindle organization in meiocytes ...
Hua Jiang +9 more
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Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation [PDF]
Cell Cycle, 2013 Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development of pancreatic cancer, the fourth leading cause of cancer-related deaths worldwide.
Xiaodong Sun +10 more
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