Results 21 to 30 of about 7,309 (206)

Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability [PDF]

Frontiers in Cell and Developmental Biology, 2021
Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly are, in turn, the major contributors to the error-prone nature of chromosome segregation in the oocytes of
Marilena Rizzo, Tom A. E. Stout, Santo Cristarella, Marco Quartuccio, Geert J.P.L. Kops, Marta de Ruijter‐Villani   +5 more
openalex   +8 more sources

Supplementary Figures from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer

, 2023
<p>Supplemental Fig S1- S6</p>
Zebin Wang, Shaun Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Xin Wang, Wenxian Wang, Farzin Gharahdaghi, Jiaquan Wu, Nancy Su, Ryan T. Howard, Michele Mayo, Dan Widzowski, David A. Scott, Jeffrey W. Johannes, Michelle L. Lamb, Deborah Lawson, Jonathan R. Dry, Paul D. Lyne, Edward W. Tate, Michael Zinda, Keith Mikule, Stephen E. Fawell, Corinne Reimer, Huawei Chen   +24 more
  +4 more sources

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering [PDF]

Cell Death & Differentiation, 2010
We have previously shown that a non-toxic noscapinoid, EM011 binds tubulin without altering its monomer/polymer ratio. EM011 is more active than the parent molecule, noscapine, in inducing G2/M arrest, inhibiting cellular proliferation and tumor growth in various human xenograft models. However, the mechanisms of mitotic-block and subsequent cell death
PRIYAMBADA KARNA, P C G Rida, Vaishali Pannu, Kalpna Gupta, W. Brian Dalton, Hanumanthachar Joshi, Vincent W. Yang, Jun Zhou, Ritu Aneja   +8 more
openalex   +3 more sources

Induction of Aneuploidy, Centrosome Abnormality, Multipolar Spindle, and Multipolar Division in Cultured Mammalian Cells Exposed to an Arsenic Metabolite, Dimethylarsinate

YAKUGAKU ZASSHI, 2016
Toxicological studies of arsenic compounds were conducted in cultured mammalian cells to investigate the effects of glutathione (GSH) depletion. Dimethylarsinate DMA(V) was not cytotoxic in cells depleted of GSH, but was found to be cytotoxic when GSH was present outside the cells.
Takafumi Ochi
openalex   +4 more sources

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. [PDF]

PLoS ONE
The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function ...
Renaldo Sutanto, Lila Neahring, Andrea Serra Marques, Mauricio Jacobo Jacobo, Seda Kilinc, Andrei Goga, Sophie Dumont   +6 more
doaj   +2 more sources

Induction of Multipolar Spindles in the Meiosis of <i>Triticum aestivum</i> as Effected by Acetone

CYTOLOGIA, 1966
In the present investigation, the treatment of pollen mother cells of Triticum aestivum with acetone provided an excellent material for multipolarity. It was possible to follow the formation of the spindle fibre apparatus in the case of multipolar anaphases.
A. Kabarity
openalex   +4 more sources

When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses

PLoS ONE, 2008
Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution.
David Gisselsson, Ulf Håkanson, Patrick Stoller, Dominik Marti, Yuesheng Jin, Anders H. Rosengren, Ylva Stewénius, Fredrik Kahl, Ioannis Panagopoulos   +8 more
openalex   +8 more sources

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces [PDF]

Molecular Cancer, 2011
Background Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation ...
Asteriti Italia A, Giubettini Maria, Lavia Patrizia, Guarguaglini Giulia   +3 more
doaj   +4 more sources

Supplemental Materials from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer

, 2023
<p>Supplemental materials</p>
Zebin Wang, Shaun Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Xin Wang, Wenxian Wang, Farzin Gharahdaghi, Jiaquan Wu, Nancy Su, Ryan T. Howard, Michele Mayo, Dan Widzowski, David A. Scott, Jeffrey W. Johannes, Michelle L. Lamb, Deborah Lawson, Jonathan R. Dry, Paul D. Lyne, Edward W. Tate, Michael Zinda, Keith Mikule, Stephen E. Fawell, Corinne Reimer, Huawei Chen   +24 more
  +4 more sources

siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells [PDF]

Insects
Silkworm ovary-derived BmN4 cells rely on chromatin-induced spindle assembly to form microtubule-based square mitotic spindles that ensure accurate segregation of holocentric chromosomes during cell division.
Bing Zhang, Camilo Ayra-Pardo, Xiaoning Liu, Meiting Song, Dandan Li, Yunchao Kan   +5 more
doaj   +2 more sources