Results 31 to 40 of about 144,088 (166)

Appropriate Mechanical Confinement Inhibits Multipolar Cell Division via Pole-Cortex Interaction

Physical Review X, 2023
Multipolar spindles are very rare in normal tissues, but they are much more prevalent in many tumors, which might be induced by the mechanical confinements from overcrowding microenvironments in tumors.
Longcan Cheng, Jingchen Li, Houbo Sun, Hongyuan Jiang   +3 more
doaj   +1 more source

Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor. [PDF]

PLoS ONE, 2013
In order to study the effect of microgravity on the proliferation of mammalian osteosarcoma cells and osteoblasts, the changes in cell proliferation, spindle structure, expression of MAD2 or BUB1, and effect of MAD2 or BUB1 on the inhibition of cell ...
Lijun Wei, Yan Diao, Jing Qi, Alexander Khokhlov, Hui Feng, Xing Yan, Yu Li   +6 more
doaj   +1 more source

Inactivation of RB1, CDKN2A, and TP53 have distinct effects on genomic stability at side‐by‐side comparison in karyotypically normal cells

Genes, Chromosomes and Cancer, Volume 62, Issue 2, Page 93-100, February 2023., 2023
Abstract Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery.
Natalie Andersson, Karim H. Saba, Linda Magnusson, Jenny Nilsson, Jenny Karlsson, Karolin H. Nord, David Gisselsson   +6 more
wiley   +1 more source

ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis.

PLoS Genetics, 2022
During mitosis, centrosomes serve as microtubule organizing centers that guide the formation of a bipolar spindle. However, oocytes of many species lack centrosomes; how meiotic spindles establish and maintain these acentrosomal poles remains poorly ...
Gabriel Cavin-Meza, Timothy J Mullen, Emily R Czajkowski, Ian D Wolff, Nikita S Divekar, Justin D Finkle, Sarah M Wignall   +6 more
doaj   +1 more source

Advanced sleep spindle identification with neural networks [PDF]

Scientific Reports 12, 7686 (2022), 2022
Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if ...
arxiv   +1 more source

Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Genome Biology, 2022
Background During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental biological tenet, we demonstrate here that parental genomes can segregate
Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom, Joris Robert Vermeesch   +13 more
doaj   +1 more source

Examining the assembly pathways and active microtubule mechanics underlying spindle self-organization [PDF]

Proc. Natl. Acad. Sci. USA 119, e2209053119 (2022), 2020
The bipolar organization of the microtubule-based mitotic spindle is essential for the faithful segregation of chromosomes in cell division. Despite our extensive knowledge of genes and proteins, the physical mechanism of how the ensemble of microtubules can assemble into a proper bipolar shape remains elusive.
arxiv   +1 more source

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

eLife, 2022
The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty, Nelly Rouquié, Cyrielle Bories, Suzanne Mélique, Valérie Duplan-Eche, Abdelhadi Saoudi, Nicolas Fazilleau, Renaud Lesourne   +7 more
doaj   +1 more source

Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. [PDF]

PLoS ONE, 2007
BACKGROUND:The Ewing sarcoma breakpoint region 1 gene (EWSR1), also known as EWS, is fused to a number of different partner genes as a result of chromosomal translocation in diverse sarcomas.
Mizuki Azuma, Lisa J Embree, Hatem Sabaawy, Dennis D Hickstein   +3 more
doaj   +1 more source

Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

Scientific Reports, 2021
We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky, Kevin Larocque, Mathieu C. Husser, Jiang Tian Liu, Pat Forgione, Alisa Piekny   +5 more
doaj   +1 more source