Characterization of the role of the tumor marker Nup88 in mitosis [PDF]
Molecular Cancer, 2010 Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup).
Yoshida Kimihisa +3 more
doaj +5 more sources
Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach [PDF]
Cell Death & Disease, 2012 Centrosome amplification (CA) and resultant chromosomal instability have long been associated with tumorigenesis. However, exacerbation of CA and relentless centrosome declustering engender robust spindle multipolarity (SM) during mitosis and may induce cell death. Recently, we demonstrated that a noscapinoid member, reduced bromonoscapine, (S)-3-(R)-9-
Vaishali Pannu +9 more
openalex +4 more sources
Kinesin-5 motors are required for organization of spindle microtubules in
BMC Plant Biology, 2006 Background Monastrol, a chemical inhibitor specific to the Kinesin-5 family of motor proteins, was used to examine the functional roles of Kinesin-5 proteins during the first, asymmetric cell division cycle in the brown alga Silvetia compressa.
Kropf Darryl L, Peters Nick T
doaj +4 more sources
Small Molecules Identified by an In Silico Docking Screen Targeting Anaphase-Promoting Complex/Cyclosome Subunit 1 (APC1) Potentiate Paclitaxel-Induced Breast Cancer Cell Death [PDF]
MoleculesDelaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar mitotic spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-
Scott C. Schuyler +4 more
doaj +2 more sources
Correction: Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. [PDF]
PLoS BiolZhou AS +8 more
europepmc +2 more sources
Molecular design principles for bipolar spindle organization by two opposing motors. [PDF]
Proc Natl Acad Sci U S ADuring cell division in animal cells, a bipolar spindle assembles to segregate the chromosomes. Various motor proteins with different properties are essential for spindle self-organization.
Chew WX, Nédélec F, Surrey T.
europepmc +3 more sources
Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease. [PDF]
JCI InsightAutosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis
Cheng T +5 more
europepmc +3 more sources
Appropriate Mechanical Confinement Inhibits Multipolar Cell Division via Pole-Cortex Interaction
Physical Review X, 2023 Multipolar spindles are very rare in normal tissues, but they are much more prevalent in many tumors, which might be induced by the mechanical confinements from overcrowding microenvironments in tumors.
Longcan Cheng +3 more
doaj +1 more source
Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor. [PDF]
PLoS ONE, 2013 In order to study the effect of microgravity on the proliferation of mammalian osteosarcoma cells and osteoblasts, the changes in cell proliferation, spindle structure, expression of MAD2 or BUB1, and effect of MAD2 or BUB1 on the inhibition of cell ...
Lijun Wei +6 more
doaj +1 more source