TUFT1 regulates cancer progression by suppressing centrosome amplification and mitotic spindle multipolarity [PDF]
Cell Death & DiseaseAbstract Centrosome amplification (CA) has been observed in various solid tumors and contributes to chromosomal instability (CIN) and poor clinical prognosis in patients with cancer. CA also inhibits cell proliferation by inducing cell-cycle arrest and cell death.
Shaojie Feng +7 more
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Vinpocetine Overcomes Paclitaxel Resistance in a Triple-Negative Breast Cancer Cell Line. [PDF]
Cell Biol IntABSTRACT Paclitaxel is a first‐line treatment for triple‐negative breast cancer (TNBC), but its efficacy is commonly limited by tumor‐cell resistance. Vinpocetine is a well‐tolerated dietary supplement with pleiotropic cellular effects, including potential anti‐tumor activity.
Kuo HH, Huang CW, Chiang WR, Yih LH.
europepmc +2 more sources
Appropriate Mechanical Confinement Inhibits Multipolar Cell Division via Pole-Cortex Interaction
Physical Review X, 2023 Multipolar spindles are very rare in normal tissues, but they are much more prevalent in many tumors, which might be induced by the mechanical confinements from overcrowding microenvironments in tumors.
Longcan Cheng +3 more
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Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor. [PDF]
PLoS ONE, 2013 In order to study the effect of microgravity on the proliferation of mammalian osteosarcoma cells and osteoblasts, the changes in cell proliferation, spindle structure, expression of MAD2 or BUB1, and effect of MAD2 or BUB1 on the inhibition of cell ...
Lijun Wei +6 more
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Colchicine Effect on the Mitotic Spindle: Estimate of Multipolar Anaphase Production
Caryologia, 1974 A study was made of the effect of colchicine on the mitotic spindle in onion root tips.The influence of temperature and time of exposure of dividing cells to the drug on the formation of multipolar...
J. P. Hervás +2 more
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The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis [PDF]
, 2020 The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids ...
Bucciarelli, Elisabetta +8 more
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Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability [PDF]
Frontiers in Cell and Developmental Biology, 2021 Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly are, in turn, the major contributors to the error-prone nature of chromosome segregation in the oocytes of
Marilena Rizzo +5 more
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Disturbed chromosome segregation and multipolar spindle formation in a patient with
Molecular Genetics & Genomic Medicine, 2017 Patients with intellectual disability (ID) typically exhibit significant defects in both intelligence and adaptive behavior. Aberration of several genes involved in proper progression of mitosis has been reported to underlie ID. Here, we report a new patient with a novel mutation of CHAMP1.Whole exome sequencing (WES) analysis was performed.
Nobuhiko Okamoto +6 more
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